... in presumptive ectoderm. Induction of HNF3β by all three GATA factors was abolished when protein synthesis was inhibited, showing that these inductions are indirect. In contrast, whereas induction of Sox17α and HNF1β by GATA4 and 5 was substantially reduced when protein synthesis was inhibited, induction...

... ¶ Deceased 18 May 2001 23 7 2004 © 2004. 2004 D2LIC Axis formation Handedness Mouse embryo Intra-flagellar transport Lefty2 Hnf3β Dynein is a large multi-subunit protein complex consisting of two heavy chains complexed to intermediate, light intermediate and/or light chains...

... neural tube is composed of distinct areas: (1) a median one (medial floor plate or MFP) derived from Hensen’s node and characterised by the same gene expression pattern as the node cells (i.e. expression of HNF3β and Shh to the exclusion of genes early expressed in the neural ectoderm such as CSox1...

...-dependent physiological interaction probably corresponds to the existence of a direct interaction between Hoxa5 and FKHR and FoxA2/HNF3β, as demonstrated by pull-down experiments achieved either in vitro or after cellular co-expression. In conclusion, we propose that the impaired growth observed...

... for specification of the ventral neural tube. It has been suggested that Shh may control its own expression in the ventral neural tube. This autoregulatory loop was proposed to involve the winged helix transcription factor HNF3β, which is both an immediate target of Shh signalling (Ruiz i Altaba et al., 1995a...

... for secreted molecules (Nodal) or transcription factors (Otx2 and HNF3β), is essential for head development (Varlet et al., 1997 ; Rhinn et al., 1998 ; Dufort et al., 1998). These findings have led to the proposal that the AVE of the mouse embryo displays head organising properties whereas the anterior...

...- terminal half results in a protein with repressor activity, while removal of the repression domain at the N terminus converts Gli2 into a strong activator. In transgenic mouse embryos, N-terminally truncated Gli2, unlike the full length protein, activates a Shh target gene, HNF3β , in the dorsal neural...

...Daniel Dufort; Lois Schwartz; Kendraprasad Harpal; Janet Rossant ABSTRACT During early embryogenesis, the transcription factor HNF3β is expressed in visceral and definitive endoderm, node, notochord and floorplate. A targeted mutation in the HNF3 β gene results in the lack of a definitive node...

... embryo SHH BMP4 Msx Pax1 Pax9 Pax6 HNF3β Much attention is currently devoted to the molecular control of paraxial mesoderm development. It has been established that the onset of the dorsoventral polarity of the epithelial somite is accompanied by the expression of transcription...

... HNF3β Sonic hedgehog Floor plate Gli2 Drosophila The Hedgehog (Hh) family of signaling molecules mediate many inductive processes during invertebrate and vertebrate development (see review by Hammerschmidt et al., 1997). In Drosophila, hh plays a vital role in determining cell fate...