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Keywords: HIF1α
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Journal Articles
Journal: Development
Development (2015) 142 (14): 2405–2412.
Published: 15 July 2015
... form. Moreover, low O 2 availability (hypoxia) impedes progenitor-dependent myogenesis in vitro through multiple mechanisms, including activation of hypoxia inducible factor 1α (HIF1α). However, whether HIF1α regulates skeletal myogenesis in vivo is not known. Here, we explored the role of HIF1α during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4473–4483.
Published: 1 December 2012
... (HIF1α) as a central component in a mechanism that underlies collagen hydroxylation and secretion by hypoxic cells. We show that Hif1a loss of function in growth plate chondrocytes arrests the secretion of extracellular matrix proteins, including collagen type II. Reduced collagen hydroxylation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (21): 3587–3597.
Published: 1 November 2008
... chondrocytes only occurred under hypoxic stress,characterized by an upregulation of unfolded protein response-related genes as well as an engorged and fragmented ER in which collagens were trapped. An upregulation of hypoxia-inducible factor 1α (HIF1α) and downstream targets followed by ER stress induction...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (9): 2161–2171.
Published: 1 May 2004
... was abolished in developing cartilage. This similarity of cell death phenotypes and the deficient VEGFA production in Hif1a null epiphyseal chondrocytes demonstrate that HIF1α and VEGFA are components of a key pathway to support chondrocyte survival during embryonic bone development. Fig. 5. Apoptosis...