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Keywords: HES-1
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Journal Articles
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
Available to PurchaseCarrie Shawber, Donna Nofziger, James J.-D. Hsieh, Claire Lindsell, Oliver Bögler, Diane Hayward, Gerry Weinmaster
Journal:
Development
Development (1996) 122 (12): 3765–3773.
Published: 1 December 1996
... transactivates the hairy and Enhancer of split (HES-1) gene. However, we describe constitutively active forms of Notch1, which inhibit muscle cell differentiation but do not interact with CBF1 or upregulate endogenous HES-1 expression. In addition, Jagged-Notch interactions that prevent the expression of muscle...
