...Naoki Mine; Ryo Iwamoto; Eisuke Mekada Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR)and ERBB4. Here, we show that HB-EGF-EGFR signaling is involved in eyelid development. HB-EGF expression...

...Xiaohong Wang; Haibin Wang; Hiromichi Matsumoto; Shyamal K. Roy; Sanjoy K. Das; Bibhash C. Paria Heparin binding EGF-like growth factor (HB-EGF), encoded by the Hegfl gene, is considered as an important mediator of embryo-uterine interactions during implantation in mice. However, it is unknown...

..., including the tangential pathway to the olfactory bulb via the rostral migratory stream (RMS), the lateral cortical stream (LCS) leading to ventrolateral cortex and the radial pathway from proliferative zones to cortical plate. The targets of these pathways express the ligands HB-EGF and/or TGFα. To test...

...Bibhash C. Paria; Klaus Elenius; Michael Klagsbrun; Sudhansu K. Dey Blastocyst implantation requires molecular and cellular interactions between the uterine luminal epithelium and blastocyst trophectoderm. We have previously shown that heparin-binding EGF-like growth factor (HB-EGF) is induced...

...Sanjoy K. Das; Xiao-Ning Wang; Bibhash C. Paria; Deborah Damm; Judith A. Abraham; Michael Klagsbrun; Glen K. Andrews; Sudhansu K. Dey ABSTRACT Heparin-binding EGF-like growth factor (HB-EGF) is a newly discovered member of the EGF family of growth factors. HB-EGF can bind to two loci on cell...