... driver of age reprogramming. Initial studies showed that the age-related decline of the H3K9me3 histone modification could be restored by partial reprogramming ( Cheng et al., 2022 ; Gill et al., 2022 ; Ocampo et al., 2016 ; Rodríguez-Matellán et al., 2020 ; Sarkar et al., 2020 ). More importantly...

... to nucleate heterochromatin, is recruited upstream of Nanog , within a region enriched for histone H3 lysine 9 tri-methylation (H3K9me3). Whereas before differentiation H3K9me3 at Nanog depends on ERK, in somatic cells it becomes independent of ERK. Moreover, the loss of H3K9me3 at Nanog , induced by deleting...

..., such as H3K9me3, in the Prss50 -null mouse testis may cause increases in post-meiosis proteins, such as AKAP4, affecting sperm formation. We provide important insights into the complex mechanisms of sperm development, the importance of testis proteases in fertility and a novel mechanism for MMAF. Competing...