...Steffen Abay-Nørgaard; Benedetta Attianese; Laura Boreggio; Anna Elisabetta Salcini ABSTRACT Post-translational histone modifications regulate chromatin compaction and gene expression to control many aspects of development. Mutations in genes encoding regulators of H3K4 methylation are causally...

... ; Couture and Skiniotis, 2013 ; Takahashi et al., 2011 ). These regulatory subunits form a subcomplex that binds the catalytic subunit and dramatically enhances its H3K4MT activity ( Patel et al., 2009 ). Depletion of any of the regulatory subunits impairs H3K4 methylation ( Steward et al., 2006 ; Dou et...

... time: gradients and signaling cascades in C. elegans . Cell   82 , 171 - 174 . 10.1016/0092-8674(95)90302-X Kidder , B. L. , Hu , G. and Zhao , K. ( 2014 ). KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation...

... of genes associated with cell cycle regulation, ion homeostasis and hypoxia signaling. KMT2D MLL2 MLL4 ALR Kabuki syndrome H3K4 methylation Heart development Mouse During heart development genes are tightly regulated to ensure expression in specific cardiac tissues at the appropriate...

...Luca Mariani; Yvonne C. Lussi; Julien Vandamme; Alba Riveiro; Anna Elisabetta Salcini The dynamic regulation of histone modifications is important for modulating transcriptional programs during development. Aberrant H3K4 methylation is associated with neurological disorders, but how the levels...

...Anita S. Bledau; Kerstin Schmidt; Katrin Neumann; Undine Hill; Giovanni Ciotta; Ashish Gupta; Davi Coe Torres; Jun Fu; Andrea Kranz; A. Francis Stewart; Konstantinos Anastassiadis Histone 3 lysine 4 (H3K4) methylation is a universal epigenetic mark. In mammals, there are six H3K4 methyltransferases...