..., we found that the SRCAP complex functioned through H2A.Z deposition to activate transcription of metabolic genes. These findings have unveiled the important physiological functions of the SRCAP complex in regulating mitochondrial maturation and promoting oxidative metabolism during heart development...

.... Changes in chromatin structure are required for the downregulation of MIR156A and MIR156C , but whether chromatin structure contributes to their initial elevated expression is unknown. We found that mutations in components of the SWR1 complex ( ARP6 , SEF ) and in genes encoding H2A.Z ( HTA9 and HTA11...

...Kenneth Börner; Peter B. Becker SWR1-type nucleosome remodeling factors replace histone H2A by variants to endow chromatin locally with specialized functionality. In Drosophila melanogaster a single H2A variant, H2A.V, combines functions of mammalian H2A.Z and H2A.X in transcription regulation...

..., the histone H2A variant HTZ-1/H2A.z and MYS-1 are required for the maintenance of cell fates in a redundant manner. BET-1 controlled the subnuclear localization of HTZ-1. HTZ-1 and MYS-1 maintained the fates of the somatic gonadal cells (SGCs) through the repression of a target, ceh-22 /Nkx2.5, which induced...