...Anne Gabory; Marie-Anne Ripoche; Anne Le Digarcher; Françoise Watrin; Ahmed Ziyyat; Thierry Forné; Hélène Jammes; Justin F. X. Ainscough; M. Azim Surani; Laurent Journot; Luisa Dandolo The imprinted H19 gene produces a non-coding RNA of unknown function. Mice lacking H19 show an overgrowth...

..., parental-specific imprinting marks are maintained to direct appropriate imprinted gene expression. We previously demonstrated that H19 imprinting could be lost during preimplantation development under certain culture conditions. To define the lability of genomic imprints during this dynamic period...

... cluster of imprinted genes. We show that the mutation is an inversion, whose breakpoint distal to H19 disrupts and thus identifies an enhancer for Igf2 expression in skeletal muscle and tongue, and separates the gene from other mesodermal and extra-embryonic enhancers. Paternal transmission of Mnt leads...

...Robert A. Drewell; Katharine L. Arney; Takahiro Arima; Sheila C. Barton; James D. Brenton; M. Azim Surani The reciprocally imprinted H19 and Igf2 genes form a co-ordinately regulated 130 kb unit in the mouse controlled by widely dispersed enhancers, epigenetically modified silencers...

...Justin F-X. Ainscough; Rosalind M. John,; Sheila C. Barton; M. Azim Surani ABSTRACT Igf2 and H19 are closely linked and reciprocally expressed genes on distal chromosome 7 in the mouse. We have previously shown that a 130 kb YAC transgene contains multiple tissue-specific enhancers for expression...

...Robert A. Drewell; James D. Brenton; Justin F.-X. Ainscough; Sheila C. Barton; Kathy J. Hilton; Katharine L. Arney; Luisa Dandolo; M. Azim Surani ABSTRACT The H19 imprinted gene is silenced when paternally inherited and active only when inherited maternally. This is thought to involve a cis -acting...

...) cells affects their totipotency and may give rise to fetal abnormalities. To investigate whether this is associated with epigenetic alterations in imprinted genes, we analysed two maternally expressed genes (Igf2r, H19) and two paternally expressed genes (Igf2, U2af1-rs1) in ES cells and in completely...

... examined Peg1/Mest, Igf2, Peg3, Snrpn, H19, Igf2r and excess p57 KIP2 . We show that paternally expressed genes, Peg1/Mest, Peg3 and Snrpn , are expressed in the parthenotes, presumably due to a lack of maternal epigenetic modifications during oocyte growth. In contrast, the expression of Igf2 , which...

... the life-time of an organism. This phenomenon is exemplified by parent-of-origin-specific inactivation events (genomic imprinting) for a subset of mammalian autosomal genes, such as H19 . Very little is known, however, about the timing and mechanism(s) of silencing of the paternal H19 allele during mouse...

...Gail I. R. Adam; Hengmi Cui; Stephen J. Miller; Folke Flam; Rolf Ohlsson ABSTRACT Precursory studies of H19 transcription during human foetal development have demonstrated maternally derived monoallelic expression. Analyses in extra-embryonic tissues, however, have been more equivocal...

...Hiroyuki Sasaki; Anne C. Ferguson-Smith; Alisa S. W. Shum; Sheila C. Barton; M. Azim Surani ABSTRACT The mouse H19 gene is imprinted so that the paternal copy is both methylated and repressed during fetal development. However, the CpG-rich promoter region encompassing the transcription start...

... for correspondence * Authors contributed equally 31 January 1994 © 1994 by Company of Biologists 1994 msd mouse mutants mesoderm induction Brachyury (T) Evx1 goosecoid Fgf4 Fgf5 Fgfr1 Fgfr2 Sna H19 The morphogenetic movements of gastrulation...

...Rolf Ohlsson; Fredrik Hedborg; Lars Holmgren; Colum Walsh; Tomas J. Ekström ABSTRACT The spatial patterns of IGF2 and H19 gene expression are strikingly similar during parts of human embryonic/fetal and early postnatal development. Notable exceptions were found with the ciliary anlage...