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Keywords: Gsk3
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Journal Articles
Journal: Development
Development (2019) 146 (13): dev164145.
Published: 02 July 2019
... GSK3 Wnt signaling β-Catenin Destruction complex Wnt-directed signal transduction is a highly conserved mechanism that controls cellular patterning, tissue development, stem cell maintenance and tissue repair in all animals ( Clevers and Nusse, 2012 ). In the canonical Wnt pathway, β-catenin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4076–4086.
Published: 01 November 2014
.... However, the regulatory mechanisms of neural progenitor homeostasis remain poorly understood. Here, we show that mammalian target of rapamycin (mTOR) is required for maintaining neural progenitor pools and plays a key role in mediating glycogen synthase kinase 3 (GSK3) signaling during brain development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1970–1980.
Published: 01 May 2013
... that in Xenopus dorsal tissues FGF and Wnt signaling quell BMP signaling by degrading phosphorylated (P) Smad1/5, the BMP pathway signal transducer, via phosphorylation of the Smad1/5 linker region. We show that in zebrafish FGF/MAPK, but not Wnt/GSK3, phosphorylation of the Smad1/5 linker region localizes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4341–4350.
Published: 15 October 2011
..., they converge on the same conserved mechanism that leads to the inactivation of TCF3-mediated repression. According to the commonly accepted scheme of the canonical Wnt signaling pathway, β-catenin is rapidly degraded by the complex of Axin, adenomatous (or adenomatosis) polyposis coli (APC) and GSK3...
Journal Articles
Journal: Development
Development (2008) 135 (2): 367–375.
Published: 15 January 2008
... of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. We demonstrated previously that Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (1): 217–228.
Published: 01 January 2004
... for expansion of cerebellar granule neuron precursors. The PI3K pathway stabilizes Nmyc1 protein via inhibition of GSK3-dependent Nmyc1 phosphorylation and degradation. The effects of PI3K activity on Nmyc1 stabilization are mimicked by insulin-like growth factor, a PI3K agonist with roles in central nervous...