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Keywords: Gsc
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Journal Articles
Journal: Development
Development (2020) 147 (2): dev182063.
Published: 15 January 2020
... that Wh promotion of Mei-p26 (a human TRIM32 ortholog) function maintains ovarian germ cell homeostasis. Wh and Mei-p26 are epistatically linked, with wh and mei-p26 mutants showing nearly identical phenotypes, including germline stem cell (GSC) loss, stem-cyst formation due to incomplete cytokinesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174615.
Published: 28 June 2019
..., its role in stem cells and niches has never been reported. Here, this study shows that the exocyst functions in the niche to promote germline stem cell (GSC) progeny differentiation in the Drosophila ovary by directly regulating EGFR membrane trafficking and signaling. Inactivation of exocyst...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev159186.
Published: 5 April 2018
... mediates dietary maintenance of Drosophila ovarian germline stem cells (GSCs) by promoting the extension of niche escort cell (EC) membranes to wrap around GSCs. This wrapping may facilitate the delivery of bone morphogenetic protein stemness factors from ECs in the niche to GSCs. In addition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (13): 2602–2610.
Published: 1 July 2014
...) is required for maintaining the association of escort cells (ECs) with germ cells in adult ovaries. This tight association is essential for germline stem cell (GSC) differentiation into cysts. Woc is also required in larval ovaries for the association of intermingled cells (ICs) with primordial germ cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 21–32.
Published: 1 January 2006
... specification, resulting in aboralized embryos. Nodal and its target Gsc each rescue oral-aboral specification and patterning when expressed asymmetrically in p38-inhibited embryos. Thus, our results indicate that p38 is required for oral specification through its promotion of Nodal expression in the oral...
Journal Articles
Journal: Development
Development (2004) 131 (9): 1881–1890.
Published: 1 May 2004
...M. Olivia Casanueva; Edwin L. Ferguson The available experimental data support the hypothesis that the cap cells(CpCs) at the anterior tip of the germarium form an environmental niche for germline stem cells (GSCs) of the Drosophila ovary. Each GSC undergoes an asymmetric self-renewal division...