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Keywords: Growth plate
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Journal Articles
Journal: Development
Development (2023) 150 (15): dev201734.
Published: 4 August 2023
... of canonical Wnt signaling, accumulated. We identified Wnt7b as a factor with increased expression in growth plate cartilage in Smad4 cKO mice. Wnt7b mRNA was expressed in differentiated chondrocytes and suppressed by BMP4 stimulation. Ablation of Wnt7b blunted the increase in bone in adult Smad4 cKO mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199826.
Published: 20 January 2022
...Diego J. Hoyle; Daniel B. Dranow; Thomas F. Schilling ABSTRACT Secreted signals in patterning systems often induce repressive signals that shape their distributions in space and time. In developing growth plates (GPs) of endochondral long bones, Parathyroid hormone-like hormone (Pthlh) inhibits...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev179325.
Published: 11 March 2020
.... However, recent in vivo tracking experiments have revealed the presence of SSCs not only within the bone marrow but also within the periosteum and growth plate reserve zone. These studies show that SSCs are highly heterogeneous with regard to lineage potential. It has also been revealed that, during digit...
Journal Articles
Journal: Development
Development (2017) 144 (19): 3533–3546.
Published: 1 October 2017
... and survival. Importantly, the Igf2 null mouse model does not represent a simple delay of growth but instead uncoordinated growth plate development. Furthermore, biochemical and two-photon imaging analyses identified elevated and imbalanced glucose metabolism in the Igf2 null mouse. Attenuation of glycolysis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2946–2957.
Published: 15 August 2016
... terminal tail vertebrae and CCs ( Fig. S23C,D ). Thus, lizard CCs developed growth plate-like organization as they underwent endochondral ossification. This entire process was absent in regenerated salamander tails. Salamander CCs contacted original tail vertebrae similar to lizard CCs ( Fig. S23E...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 348–355.
Published: 15 January 2016
...Eva S. Liu; Adalbert Raimann; Byongsoo Timothy Chae; Janaina S. Martins; Manuela Baccarini; Marie B. Demay Extracellular phosphate plays a key role in growth plate maturation by inducing Erk1/2 (Mapk3/1) phosphorylation, leading to hypertrophic chondrocyte apoptosis. The Raf kinases induce Mek1/2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 817–831.
Published: 1 March 2015
... recent findings regarding the roles of several signaling pathways in modulating the proliferation and maturation of chondrocytes in the growth plate, which is the ‘engine’ of bone elongation. References Ahrens , P. B. , Solursh , M. and Reiter , R. S. ( 1977 ). Stage-related...
Journal Articles
Journal: Development
Development (2012) 139 (23): 4473–4483.
Published: 1 December 2012
... production to oxygenated cells. However, during embryogenesis, cells in different tissues that develop under low oxygen levels must produce this essential protein. In this study, using the growth plate of developing bones as a model system, we identify the transcription factor hypoxia-inducible factor 1 α...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (7): 1093–1104.
Published: 1 April 2009
... BMP Smad Growth plate Chondrogenesis Mouse Bone morphogenetic proteins (BMPs) and their receptors are required for chondrogenesis and are expressed throughout the growth plate and perichondrium( Retting and Lyons, 2006 ; Yoon and Lyons, 2004 ; Minina et al., 2005 ; Minina et al., 2001...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (22): 5717–5725.
Published: 15 November 2004
... in embryos and newborns leads to reduced zones of hypertrophic chondrocytes and impaired matrix deposition in femoral and tibial growth plates, probably owing to impaired differentiation into hypertrophic chondrocytes. In addition, hypertrophic differentiation and ossification of primordial arches...
Journal Articles
Journal Articles