... or indirectly activate blood-borne factors with long-range signaling properties. Skeletal muscle satellite cells in mice have been proposed to adopt the G alert state in response to hepatocyte growth factor activator (HGFA; HGFAC) ( Rodgers et al., 2017 ). The inactive precursor of HGFA, pro-HGFA...

... Asymmetric cell division Centrosome Growth factors Primary microcephaly During embryonic development in higher vertebrates, the brain and anterior spinal cord are formed through primary neurulation of the embryonic neural plate, which produces a hollow neural tube (NT) that acts as the primordium...

... by The Company of Biologists Ltd 2017 Summary: This Primer discusses the complex embryo-uterine interactions that induce, maintain and reactivate the blastocyst from diapause, highlighting the roles of hormones, cytokines and growth factors across animal species. Embryo Diapause Uterus...

...Yongyou Zhang; Jue Zhang; Yongshun Lin; Yongsheng Lan; Chunhong Lin; Jim W. Xuan; Michael M. Shen; Wallace L. McKeehan; Norman M. Greenberg; Fen Wang The fibroblast growth factor (FGF) regulates a broad spectrum of biological activities by activation of transmembrane FGF receptor (FGFR) tyrosine...

... of Pharmaceutical Sciences, Program in Molecular and Cellular Biology, Oregon State University, Corvallis, OR 9731,USA 30 5 2007 © 2007. 2007 Alopecia Hair cycle Growth factors EGF TPA Wnt pathway Homologous recombination The general transcription factor TFIID is composed...

... the activation of the arterial markers ephrinB2 and neuropilin 1. * Author for correspondence (e-mail: [email protected] ) 17 10 2003 © 2004. 2004 Arterial-venous differentiation Hemodynamic forces Growth factors Receptors Ephrin Neuropilin In the adult...

...Andy J. Fischer; Blair D. Dierks; Thomas A. Reh Neural progenitors at the retinal margin of the post-hatch chicken normally produce amacrine and bipolar cells, but not photoreceptor or ganglion cells. The purpose of this study was to test whether exogenous growth factors influence the types...

...Geeta S. Vemuri; F. Arthur McMorris ABSTRACT Signal transduction in response to several growth factors that regulate oligodendrocyte development and survival involves the activation of phosphatidylinositol 3-kinase, which we detect in oligodendrocytes and their precursors. To investigate the role...

... in which purified HMP1, anti-HMP1 IgG, or suspected substrates of HMP1 (e.g. growth factors such as TGF-β 1 ) were introduced into the inter-epithelial compartment of hydra using a ‘DMSO loading’ procedure. These studies indicated that HMP1 has a functional role during a number of developmental processes...

... precursors. When the nonlimbic precursors are grown on Matrigel, there is a 2-fold increase in the number of MAP2 + /LAMP + double-labeled neurons. Dissection of the Matrigel components reveals that in combination with growth factor-deficient Matrigel or collagen type IV, epidermal growth factor...

...Choy May Chia; Robert M. L. Winston; Alan H. Handyside ABSTRACT Epidermal growth factor (EGF) and transforming growth factor alpha (TGF-α) through their common receptor, epidermal growth factor receptor (EGFR) are known to enhance mitogenesis, development and implantation in several species...

... (data not shown); this revealed that after the first 5 days in culture the buds cultured in the presence of TGF-β1 were not detectably different from those cultured in the absence of the growth factor, i.e. they contained well-developed acini formed by zymogen granule-containing cells. Incorporation...

...Patricia A. Labosky; Denise P. Barlow; Brigid L. M. Hogan ABSTRACT Primordial germ cells of the mouse cultured on feeder layers with leukemia inhibitory factor, Steel factor and basic fibroblast growth factor give rise to cells that resemble undifferentiated blastocyst-derived embryonic stem cells...

.... and Skoog , F. ( 1965 ). Organic growth factor requirements of tobacco tissue culture . Physiol. Plant . 18 , 100 – 127 . 10.1111/j.1399-3054.1965.tb06874.x Matzke , M. and Matzke , A. J. M. ( 1993 ). Genomic imprinting in plants: Parental effects and trans -inactivation...

... histogenesis growth factors myoblast differentiation Myoblast heterogeneity has now been recognized as a relevant feature of developing skeletal muscle, leading to cell autonomous specification of lineage, stage and position identity ( Stockdale and Miller, 1987 ; Cossu and Molinaro, 1987 ; Miller...

...Robert A. Cornell; David Kimelman ABSTRACT The early patterning of mesoderm in the Xenopus embryo requires signals from several intercellular factors, including mesoderm-inducing agents that belong to the fibroblast growth factor (FGF) and TGF-β families. In animal hemisphere explants (animal caps...

..., indistinguishable from control blastula caps ( Fig. 9A ). Therefore, Xwnt -5A is not a mesoderm inducing growth factor in this assay. Fig. 9. Effects of overexpression of Xwnt -5A on the differentiation of isolated blastula caps. Histological examination of blastula caps from control embryos...

...Rosanna Dono; Lorenzo Scalera; Francesco Pacifico; Dario Acampora; M. Graziella Persico; Antonio Simeone ABSTRACT The murine cripto gene encodes a 171-aminoacid epidermal growth factor-related protein, with 93% similarity to its human counterpart in the ‘EGF-like’ domain. The murine cripto mRNA...

.... These observations support a model in which mesoderm is induced in vivo by a combined action of several different signals. 26 04 1933 © 1993 by Company of Biologists 1993 mesoderm induction Wnt Xenopus growth factors Induction of mesoderm is thought to be the first step...

...Josephine C. Adams; Fiona M. Watt Introduction Evidence that cell-ECM interactions regulate differentiation and development Developmental mutations Experimental perturbation of embryonic development Cell and organ cultures Regulatory mechanisms ECM diversity Interactions of growth factors...