...Hannah J. Glover; Holly Holliday; Rachel A. Shparberg; David Winkler; Margot Day; Michael B. Morris ABSTRACT The amino acid L-proline exhibits growth factor-like properties during development – from improving blastocyst development to driving neurogenesis in vitro . Addition of 400 μM L-proline...

...Yongshun Lin; Guoqin Liu; Yongyou Zhang; Ya-Ping Hu; Kai Yu; Chunhong Lin; Kerstin McKeehan; Jim W. Xuan; David M. Ornitz; Michael M. Shen; Norman Greenberg; Wallace L. McKeehan; Fen Wang The fibroblast growth factor (FGF) family consists of 22 members and regulates a broad spectrum of biological...

...Emmanuel Garcion; Aida Halilagic; Andreas Faissner; Charles ffrench-Constant Stem cells in the embryonic mammalian CNS are initially responsive to fibroblast growth factor 2 (FGF2). They then undergo a developmental programme in which they acquire epidermal growth factor (EGF) responsiveness...

... does not occur in VegT-depleted embryos. We test whether these growth factors may be endogenous factors in mesoderm induction, by studying their ability to rescue the phenotype of VegT-depleted embryos, when their expression is restricted to the vegetal mass. We find that Xnr1, Xnr2, Xnr4 and derrière...

...Bibhash C. Paria; Klaus Elenius; Michael Klagsbrun; Sudhansu K. Dey Blastocyst implantation requires molecular and cellular interactions between the uterine luminal epithelium and blastocyst trophectoderm. We have previously shown that heparin-binding EGF-like growth factor (HB-EGF) is induced...

...Kazuo Kawamura; Tatsuhiro Shibata; Olivier Saget; David Peel; Peter J. Bryant ABSTRACT By fractionating conditioned medium (CM) from Drosophila imaginal disc cell cultures, we have identified a family of Imaginal Disc Growth Factors (IDGFs), which are the first polypeptide growth factors...

...Jane F. Wiesen; Peter Young; Zena Werb; Gerald R. Cunha ABSTRACT Stromal-epithelial interactions are critical in determining patterns of growth, development and ductal morphogenesis in the mammary gland, and their perturbations are significant components of tumorigenesis. Growth factors...

...Philippe Soriano ABSTRACT Platelet-derived growth factors (PDGFs) have been implicated in the control of cell proliferation, survival and migration. Patch mutant mice harbor a deletion including the PDGF α receptor gene and exhibit defects of neural crest origin which affect pigmentation...

... in this communication indicate that the elevated level of fetal fibroblast migration into 3D-collagen gels and HA synthesis by these cells were not affected by epidermal growth factor (EGF), platelet-derived growth factor (PDGF), acidic fibroblast growth factor (aFGF) or basic fibroblast growth factor (bFGF...

..., B. M. (1996) J. Cell Biol . 132, 1105-1114). Induction of Siamois expression was detected by RT-PCR. Of the four growth factors, only Wnt was sensitive to inhibition of β-catenin activity and only Wnt could induce Siamois expression. Therefore, Wnt is able to induce a bonafide Nieuwkoop Center...

... cells. * Author for correspondence (e-mail: [email protected] ) 03 07 1996 © 1996 by Company of Biologists 1996 cell death apoptosis tPA AFP Brachyury Endo A myosin muscle epidermal growth factor receptor growth factor stem cell The proto-oncogene epidermal...

.... M. are both first authors 19 5 1996 © 1996 by Company of Biologists 1996 TGFβ apoptosis growth factor Msx-1 Msx-2 ck-erg BMP-4 cell death chick limb bud autopod The developing limb bud is a relatively simple structure consisting of mesoderm covered...

...Malcolm Moos, Jr; Shouwen Wang; Marie Krinks ABSTRACT We have identified a novel growth factor in Xenopus , which is most closely related to human Bone Morphogenetic Protein-3. Its expression peaks during gastrulation, most prominently in the Spemann organizer, and persists in the posterior neural...

..., suggesting that vegetal cells may be prevented from expressing mesodermal genes in response to the signals that they secrete. We show here that addition of low levels of basic fibroblast growth factor (bFGF) induces the ectopic expression of the mesodermal markers Xbra, MyoD and muscle actin in vegetal...

... 7.5 day embryos and TIMP-3 transcripts were strongly expressed in the decidua imme-diately adjacent to the implanting embryo. uPA transcripts were preferentially expressed in the ectoplacental cone and its derivatives. Because these proteinases are regulated by growth factors and cytokines in other...

... insertional mutation TGFβ growth factor nodal gastrulation Despite intensive investigation, it has proved difficult to characterize genes acting to control gastrulation in mammalian embryos. Recent studies in other vertebrate systems, most notably Xenopus , have demonstrated that growth factors...

... CSF-1, suggesting that they are exclusively locally regulated by this growth factor. Langer-hans cells, bone marrow monocytes and macrophages of the thymus and lymph nodes were not significantly affected by circulating CSF-1 nor decreased in op/op mice, consistent with their regulation by other growth...

...Ellen H. Filvaroff; Reinhard Ebner; Rik Derynck ABSTRACT Transforming growth factor-β (TGF-β? is thought to play a role in mesenchymal cell development and, specifically, in muscle differentiation, yet its precise role in the latter process remains unclear. TGF-β has been shown to both inhibit...

... cells in the anterior segment of the embryonic eye. When the anterior chamber was opened briefly, by tearing the cornea or displacing the lens, the growth-promoting activity was lost. None of the purified growth factors tested replaced this growth activity, including EGF, bFGF, PDGF, IGF-1, IGF-2, TGF...

...-ponents of the extracellular matrix. * Present address: British Biotechnology, 4-10 The Quadrant, Barton Lane, Abingdon, Oxon OX14 3YS, UK † Author for correspondence 15 09 1992 © 1992 by Company of Biologists 1992 embryonic stem cells growth factor heparin...