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Keywords: Growth cone
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Journal Articles
Journal: Development
Development (2021) 148 (18): dev199717.
Published: 30 July 2021
...Cory J. Weaver; Fabienne E. Poulain ABSTRACT Since the pioneering work of Ramón y Cajal, scientists have sought to unravel the complexities of axon development underlying neural circuit formation. Micrometer-scale axonal growth cones navigate to targets that are often centimeters away. To reach...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4658–4672.
Published: 15 December 2017
...Melissa A. Borgen; Dandan Wang; Brock Grill Axon termination is essential for efficient and accurate nervous system construction. At present, relatively little is known about how growth cone collapse occurs prior to axon termination in vivo . Using the mechanosensory neurons of C. elegans , we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (3): 449–460.
Published: 01 February 2016
...Abhishek Sahasrabudhe; Ketakee Ghate; Sampada Mutalik; Ajesh Jacob; Aurnab Ghose Growth cone filopodia are actin-based mechanosensory structures that are essential for chemoreception and the generation of contractile forces necessary for directional motility. However, little is known about...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4395–4405.
Published: 15 November 2014
...Adam D. Norris; Lakshmi Sundararajan; Dyan E. Morgan; Zachary J. Roberts; Erik A. Lundquist UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and repulsion. We previously discovered that attractive UNC-40/DCC receptor signaling stimulates growth cone filopodial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (2): 335–345.
Published: 15 January 2012
... found in retinal EphA knock-in mice. Nonetheless, it is based on a single constraint of topographic growth cone navigation: the balancing of ephrin-A/EphA forward and reverse signaling. * Author for correspondence ( franco.weth@kit.edu ) Competing interests statement The authors declare...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4433–4442.
Published: 15 October 2011
...Adam D. Norris; Erik A. Lundquist The UNC-6/netrin guidance cue functions in axon guidance in vertebrates and invertebrates, mediating attraction via UNC-40/DCC family receptors and repulsion via by UNC-5 family receptors. The growth cone reads guidance cues and extends lamellipodia and filopodia...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (21): 3531–3541.
Published: 01 November 2008
... portion of the pathway, highlighting a novel cell-autonomous mechanism by which Shh can influence growth cone behaviour. In non-mammalian vertebrates, FGF signalling triggers the onset of neurogenesis that generates the first neurons, the RGCs( Martinez-Morales et al.,2005 ). Newborn RGCs begin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (17): 2855–2864.
Published: 01 September 2008
...Simon W. Moore; James P. Correia; Karen Lai Wing Sun; Madeline Pool; Alyson E. Fournier; Timothy E. Kennedy Molecular cues, such as netrin 1, guide axons by influencing growth cone motility. Rho GTPases are a family of intracellular proteins that regulate the cytoskeleton, substrate adhesion...
Journal Articles
Journal: Development
Development (2008) 135 (2): 333–342.
Published: 15 January 2008
.... Chemotropic assays reveal that S1P elicits fast repulsive responses in retinal growth cones. These responses require heparan sulfate, are sensitive to inhibitors of proteasomal degradation, and involve RhoA and LIM kinase activation. Together, the data identify downstream components that mediate S1P-induced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3251–3257.
Published: 15 September 2007
...Kelly A. Palaisa; Michael Granato One of the earliest guidance decisions for spinal cord motoneurons occurs when pools of motoneurons orient their growth cones towards a common,segmental exit point. In contrast to later events, remarkably little is known about the molecular mechanisms underlying...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (4): 713–722.
Published: 15 February 2007
... -sensitive axonal phenotype characterized by axonal looping in stage-13 embryos. Further analyses of individual, labeled neuroblast lineages revealed abnormally structured growth cones in these animals. Cell-type-specific rescue experiments demonstrate that β-Spectrin is required autonomously and non...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (5): 937–947.
Published: 01 March 2006
...Mika Sato-Maeda; Hiroshi Tawarayama; Masuo Obinata; John Y. Kuwada; Wataru Shoji In order for axons to reach their proper targets, both spatiotemporal regulation of guidance molecules and stepwise control of growth cone sensitivity to guidance molecules is required. Here, we show that, in zebrafish...
Journal Articles
Journal: Development
Development (2005) 132 (15): 3371–3379.
Published: 01 August 2005
... in guidance at the optic chiasm and the target, while either a different MMP or an ADAM is required for axons to make the turn in the mid-diencephalon. * Author for correspondence (e-mail: smcfarla@ucalgary.ca ) 18 5 2005 ©2005. 2005 Xenopus laevis MMP2 MMP9 Growth cone Target...
Journal Articles
Journal: Development
Development (2003) 130 (20): 4999–5008.
Published: 15 October 2003
... the opposite leading axon across the midline. These data suggest a simple model where the level of growth cone exposure to midline cues and presence of other axons as a substrate shape the midline kinetics of commissural axons. * Author for correspondence (e-mail: sefraser@caltech.edu ) 1 7...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (4): 775–784.
Published: 15 February 2003
.... In identifying additional molecules regulating this process during embryonic mouse development, we found that transmembrane Semaphorin5A mRNA and protein was specifically expressed in neuroepithelial cells surrounding retinal axons at the optic disc and along the optic nerve. Given that growth cone responses...
Journal Articles
Journal: Development
Development (2001) 128 (20): 4079–4092.
Published: 15 October 2001
... and demonstrate that it is required to stabilize the differentiated structure of the nervous system. In unc-119 mutants, motor neuron commissures are excessively branched in adults. However, live imaging demonstrated that growth cone behavior during extension was fairly normal with the exception that the overall...
Journal Articles
Journal: Development
Development (1991) 113 (Supplement_2): 131–139.
Published: 01 April 1991
...Roger J. Keynes; Karen F. Jaques; Geoffrey M. W. Cook The guidance of axons during embryonic development is likely to involve both adhesive and repulsive interactions between growth cones and their environment. We are characterising the role and mechanism of repulsion during the segmental outgrowth...
Journal Articles
Journal: Development
Development (1986) 95 (1): 37–52.
Published: 01 June 1986
... of the other? To what extent is the pattern of nerve Key words: limb innervation, chick limb bud, axonal guidance, motoneurone, sensory nerve, growth cone. 38 G . J . SWANSON AND J . LEWIS branches formed by the one set of fibres dependent on the other? Are the pioneer fibres that make the initial selection...
Journal Articles
Journal: Development
Development (1985) 86 (1): 155–167.
Published: 01 April 1985
...John Y. Kuwada Numerous investigations of pathfinding by embryonic neurons, including many leech neurons, have demonstrated that pathfinding is precise. Neurons project the correct number of growth cones which grow to their target areas by making specific choices along the way. However, one leech...