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Keywords: Groucho
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Journal Articles
Journal: Development
Development (2016) 143 (24): 4631–4642.
Published: 15 December 2016
...) daughters. We have identified two proteins, Six4 and Groucho (Gro), that link the activity of these two pathways to regulate the earliest cell fate decision in the FSC lineage. Our data indicate that Six4 and Gro promote differentiation towards the polar cell fate by promoting Notch pathway activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1442–1452.
Published: 1 April 2014
... differentiation of the cap mesenchyme. Furthermore, although both Six2 and Osr1 could form protein interaction complexes with TCF proteins, Osr1, but not Six2, enhances TCF interaction with the Groucho family transcriptional co-repressors. Moreover, we demonstrate that loss of Osr1 results in β-catenin/TCF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4256–4265.
Published: 15 October 2013
... more than one, with Drosophila Brinker (Brk) recruiting the co-repressors CtBP and Groucho (Gro), in addition to possessing a third repression domain, 3R. Previous studies indicated that Gro is sufficient for Brk to repress targets in the wing, questioning why it should need to recruit CtBP, a short...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (19): 3311–3322.
Published: 1 October 2009
... not involve the formation of a secondary midbrain-hindbrain boundary organizer, but instead requires direct interaction with Otx2. Using an Otx2-dependent reporter assay we demonstrate that Meis2 competes with the Groucho co-repressor Tle4 (Grg4) for binding to Otx2 and thereby restores Otx2 transcriptional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (7): 1211–1221.
Published: 1 April 2009
... to signaling pathways. The complex phenotypes are explained by Bowl repressing the Wingless pathway, the earliest effect seen. In addition, Bowl sequesters the general co-repressor Groucho from repressor complexes functioning in the Notch pathway and in Hedgehog expression, leading to ectopic activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (5): 829–837.
Published: 1 March 2008
... understood. We have previously shown that the EGFR RTK pathway causes phosphorylation and downregulation of Groucho, a global co-repressor that is widely used by many developmentally important repressors for silencing their various targets. Here, we use specific antibodies that reveal the dynamics of Groucho...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4409–4414.
Published: 15 November 2006
... by recruiting the co-repressor Groucho. However, repression occurs only when Dorsal-binding sites are close to binding sites for other factors that also bind Groucho. The need for additional factors to assist Dorsal in repression may result from the intrinsically weak interaction between Dorsal and Groucho...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (22): 5385–5400.
Published: 15 November 2003
... alone was able to provide a weak, partial rescue of the mutant phenotype,while both the Groucho-dependent and -independent repressor domains contributed equally to full rescue of each aspect of the mutant phenotype. Complete rescue was also obtained with a chimeric protein containing the Eve HD...
Journal Articles
Journal: Development
Development (2003) 130 (3): 451–462.
Published: 1 February 2003
...-mail: nakamura@idac.tohoku.ac.jp ) groucho En Cell fate Lamination Retinotectal projection Remodeling Virus-sensitive and conventionally raised fertile chick eggs were purchased from Nisseiken and from a local farm, respectively. They were incubated at 38°C in a humidified...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3585–3596.
Published: 1 August 2002
... the identity of the lateral trunk and dorsal branch cells. No ocelli (Noc) is the Drosophila protein most similar to ElB. Mutations in noc give rise to a similar tracheal phenotype. Noc is capable of associating with ElB, suggesting that they can function as a heterodimer. ElB also associates with the Groucho...
Journal Articles
Journal: Development
Development (2002) 129 (12): 2835–2849.
Published: 15 June 2002
... and Grg5, mouse counterparts of the Drosophila transcriptional co-repressor Groucho, interact with mouse Six3 and its closely related member Six6, which may also be involved in vertebrate eye development. The specificity of the interaction was validated by co-immunoprecipitation of Six3 and Grg4 complexes...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4361–4370.
Published: 1 November 2001
...Yiorgos Apidianakis; Diane Grbavec; Stefano Stifani; Christos Delidakis Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes...