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Keywords: Gremlin 1
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Journal Articles

Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth

Rushikesh Sheth, Damien Grégoire, Annie Dumouchel, Martina Scotti, Jessica My Trang Pham, Stephen Nemec, Maria Félix Bastida, Marian A. Ros, Marie Kmita
Journal: Development
Development (2013) 140 (10): 2130–2138.
https://doi.org/10.1242/dev.089409
Published: 15 May 2013
... of which relies on a positive-feedback loop involving sonic hedgehog (Shh) and the BMP antagonist gremlin 1 (Grem1). The positive cross-regulation between Shh and the HoxA and HoxD clustered genes identified an indirect effect of Hox genes on the maintenance of AER-FGFs but the respective function of Shh...
View articletitled, Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth
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Includes: Supplementary data
Journal Articles

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

Odyssé Michos, Alexandre Gonçalves, Javier Lopez-Rios, Eva Tiecke, Florence Naillat, Konstantin Beier, Antonella Galli, Seppo Vainio, Rolf Zeller
Journal: Development
Development (2007) 134 (13): 2397–2405.
https://doi.org/10.1242/dev.02861
Published: 1 July 2007
... the extra-cellular BMP antagonist gremlin 1 ( Grem1 ), metanephric development is disrupted at the stage of initiating ureteric bud outgrowth. Treatment of mutant kidney rudiments in culture with recombinant gremlin 1 protein induces additional epithelial buds and restores outgrowth and branching. All...
View articletitled, Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis
Open the PDF for Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis in another window
Includes: Supplementary data