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Keywords: Granule cell
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Journal Articles
Journal: Development
Development (2014) 141 (21): 4031–4041.
Published: 1 November 2014
... insights, our understanding of the origins of different neuronal subtypes within the cerebellar anlage has been transformed in recent years. A key clarifying concept was identification of the origins of granule cell precursors at the rhombic lip, a thin strip of neuroepithelium that borders the non...
Journal Articles
Journal: Development
Development (2013) 140 (13): 2823–2827.
Published: 1 July 2013
...Felix B. Kleine Borgmann; Oliver Bracko; Sebastian Jessberger Neural stem/progenitor cells (NSPCs) generate new neurons throughout life in the mammalian hippocampus. Newborn granule cells mature over several weeks to functionally integrate into the pre-existing neural circuitry. Even though...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2957–2968.
Published: 15 July 2011
... signalling, during cerebellar development in the mouse. Simultaneous deletion of more than one of these genes resulted in a number of defects, including mediolateral expansion of the cerebellar vermis, reduced thickness of the granule cell layer and abnormal foliation. Analysis of cerebellar development...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (4): 965–972.
Published: 15 February 2002
... for migration on glial fibers. To examine the function of astrotactin in vivo, we generated a null mutation by targeted gene disruption. The cerebella of astrotactin null mice are approximately 10% smaller than wild type. In vitro and in vivo cerebellar granule cell assays show a decrease in neuron-glial...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (1999) 126 (20): 4395–4404.
Published: 15 October 1999
... boundary of the presumptive cerebellum at E6 maps to the caudal boundary of rhombomere 1. By fate mapping the dorsoventral axis of rhombomere 1, we demonstrate that granule cell precursors are generated at the rhombic lip together with neurons of the lateral pontine nucleus. DiI-labelling of cerebellum...
Journal Articles
Journal: Development
Development (1998) 125 (1): 41–50.
Published: 1 January 1998
... in the cerebellar primordia. In Unc5h3 mutant embryos, both the development and initial migration of Purkinje cell progenitors occur as in wild-type controls. The rhombic lip, from which granule cell precursors arise, also appears to form normally in mutants. However, at E13.5, an abnormal subpopulation of granule...