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Keywords: Gradient
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Journal Articles
Journal: Development
Development (2022) 149 (7): dev200332.
Published: 8 April 2022
... results lead to two major conclusions. First, both LBS number and configuration impact cluster activity: LBSs act additively in trans and synergistically in cis . Second, the SYGL-1 gradient promotes self-renewal above its functional threshold and triggers differentiation below the threshold. Our approach...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196113.
Published: 20 January 2021
... 138 , 915 - 924 . 10.1242/dev.057729 Al Asafen , H. , Bandodkar , P. U. , Carrell-Noel , S. , Schloop , A. E. , Friedman , J. and Reeves , G. T. ( 2020 ). Robustness of the Dorsal morphogen gradient with respect to morphogen dosage . PLoS Comput. Biol. 16...
Journal Articles
Journal: Development
Development (2019) 146 (3): dev168955.
Published: 1 February 2019
... polarised along a tissue axis. We propose that these bridges provide a general mechanism by which cells interpret different forms of tissue gradients to coordinate directional information. We illustrate this using a generalised and consistent modelling framework, providing a conceptual basis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1876–1886.
Published: 15 May 2017
... and cell shape in the Drosophila mesoderm. We found that cells within the ventral domain accumulate different amounts of active apical non-muscle myosin 2 depending on the distance from the ventral midline. This gradient in active myosin depends on a newly quantified gradient in upstream signaling proteins...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4149–4160.
Published: 15 November 2016
...Miquel Sureda-Gómez; José M. Martín-Durán; Teresa Adell The β-catenin-dependent Wnt pathway exerts multiple context-dependent roles in embryonic and adult tissues. In planarians, β-catenin-1 is thought to specify posterior identities through the generation of an anteroposterior gradient. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 729–736.
Published: 15 February 2014
... that cytoneme-mediated signaling is a dispersal mechanism that delivers signaling proteins directly at sites of cell-cell contact. References Ben-Zvi D. , Pyrowolakis G. , Barkai N. , Shilo B. Z. ( 2011 ). Expansion-repression mechanism for scaling the Dpp activation gradient...
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (14): 2917–2922.
Published: 15 July 2013
... debate whether the Dpp gradient is required for the uniform cell proliferation observed in the wing imaginal disc. Here, we investigated how the Dpp signaling pathway regulates proliferation during wing development. By systematic manipulation of Dpp signaling we observed that it controls proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1621–1638.
Published: 15 April 2013
...Patrick Müller; Katherine W. Rogers; Shuizi R. Yu; Michael Brand; Alexander F. Schier The graded distribution of morphogens underlies many of the tissue patterns that form during development. How morphogens disperse from a localized source and how gradients in the target tissue form has been under...
Journal Articles
Journal: Development
Development (2012) 139 (19): 3665–3674.
Published: 1 October 2012
... of asymmetric bridges, made between Stan and Stan plus Fz, that link it with its neighbouring cells. We propose that cells normally use this mechanism to read the local slope of tissue-wide gradients of Fz activity, so that all cells come to point in the same direction. ‡ Author for correspondence ( gs20...
Journal Articles
Journal: Development
Development (2012) 139 (4): 625–639.
Published: 15 February 2012
... cells remain (see Box 6 ). In the next section, we discuss the slowing and arrest of oscillations at the tissue level. Somite progenitor cells have access to several gradients of positional information across the PSM that arise from release and propagation of signaling molecules from the somites...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 551–561.
Published: 15 February 2009
... in cells producing the TGFα-like ligand Gurken,but not in EGFR-expressing cells. Strikingly, we find that GSLs are not essential for Gurken trafficking and secretion. However, we characterize for the first time the extracellular Gurken gradient and show that GSLs affect its formation by controlling Gurken...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 461–472.
Published: 1 February 2009
... of XRDH10 and XRALDH2 constitute a`biosynthetic enzyme code' for the establishment of a morphogen gradient in the embryo. Xenopus laevis embryos and explants were obtained, cultured,microinjected and subjected to whole-mount in situ hybridization and lineage tracing as described ( Hou et al.,2007...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3339–3348.
Published: 15 September 2007
...Lisa M. Galli; Tiffany L. Barnes; Stephanie S. Secrest; Tatsuhiko Kadowaki; Laura W. Burrus A long-term goal of developmental biology is to understand how morphogens establish gradients that promote proper tissue patterning. A number of reports describe the formation of the Wg (Wnt1) gradient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1997) 124 (19): 3703–3714.
Published: 1 October 1997
... 1997 by Company of Biologists 1997 hedgehog engrailed pattern formation segment polarity gradient compartment Drosophila The epidermis of the embryonic segments and imaginal discs of Drosophila is organized into lineage compartments defined by expression of selector genes...
Journal Articles
Journal Articles
Journal: Development
Development (1997) 124 (1): 79–89.
Published: 1 January 1997
... transmits more of the DPP signal than does SAX. Our results are consistent with a model in which a gradient of DPP reaches all cells in the developing wing blade to direct anterior-posterior pattern. * Present address: Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA...
Journal Articles
Journal: Development
Development (1995) 121 (11): 3561–3572.
Published: 1 November 1995
... 1995 © 1995 by Company of Biologists 1995 orthodenticle Drosophila imaginal discs gradient engrailed pattern formation The results described can be explained by three possible models. In the first, different OTD levels would be required simply for cell proliferation...
Journal Articles
Journal Articles
Journal: Development
Development (1995) 121 (5): 1273–1282.
Published: 1 May 1995
... system ( Fig. 11B ). This leads to a comparatively rapid expression of tentacle markers. Since the hypostome has not yet appeared, the tentacle system first establishes itself at the highest available gradient value, which is found at the apical tip of the regenerate ( Fig. 8A ). When the hypostome...