... populations suggested that colonic recovery from colitis-like injury depends on multiple Wnt-producing sources. TEM procedures have been described previously ( Gao and Kaestner, 2010 ; Sakamori et al., 2012 ). For Gpr177 immunogold labeling and EM analysis, duodenal and jejunal tissues were dissected from...

... the homeostasis of adult tissues. Wnt signaling is a crucial regulator of the stem cell niche, but the mechanism that governs Wnt ligand delivery in this compartment has not been fully investigated. We identified that Wnt secretion is partly dependent on Rab8a-mediated anterograde transport of Gpr177 (wntless...