... on a single neuronal cell type. Here we provide a mechanistic understanding of how MP3, the precursor to the H-cell, forms and acquires its identity. We show that the gooseberry / gooseberry-neuro ( gsb / gsb-n ) transcription factor genes act to specify MP3 cell fate. It is proposed that single-minded...

... divergent roles in this process. Understanding the details of this variation should shed light on the evolution of the genetic hierarchy responsible for segmentation in Drosophila and other insects. We have investigated the expression of homologs of the Drosophila Pax group III genes paired, gooseberry...

... to former reports, we did not find any evidence for a direct role of hedgehog in the process of NB 7-3 specification. Instead, we present evidence to show that the interplay of the segmentation genes naked cuticle ( nkd ) and gooseberry ( gsb ), both of which are targets of wingless ( wg ) activity, leads...

... show that Gooseberry (Gsb) prevents Wg from specifying NB4-2 identity to the wg -expressing NB5-3. In this paper, we also show that gsb interacts with slp and prevents Slp from specifying NB4-2 identity. Overexpression of slp overcomes this antagonistic interaction and respecifies NB5-3 as NB4-2...

...Molly Duman-Scheel; Xuelin Li; Irena Orlov; Markus Noll; Nipam H. Patel ABSTRACT In addition to their role in the specification of the epidermal pattern in each segment, several segment polarity genes, including gooseberry (gsb) , specify cell fate in the Drosophila central nervous system (CNS...

...Krishna Moorthi Bhat; Paul Schedl ABSTRACT During neurogenesis, the transmembrane protein Patched (Ptc) promotes a wingless ( wg )-mediated specification of a neuronal precursor cell, NB4-2, by repressing gooseberry ( gsb ). In this study, novel interactions of these genes with engrailed ( en...

... expression in distinct but overlapping clusters of neuroectodermal cells and neuroblasts, whereas the nuclear Engrailed and Gooseberry proteins repress huckebein expression in specific regions of neuroectoderm or neuroblasts. Integration of these activation and repression inputs is required to establish...

..., parallel pathways and loss of either is compensated for by the other in NB 7–3 formation. NBs 6–4 and 7–3, arising from the engrailed domain, were also found to be specified by the differential expression of two homeobox genes, gooseberry-distal and engrailed . * Author for correspondence (e...

.... ChuLaGraff and C. Q. Doe (1993) Science 261, 1594-1597). The lack of autocrine specification of NB4-2 in Wg-expressing cells suggests that the response to Wg is spatially restricted, presumably through the activity of the Wg-receptor. I show that two other proteins, a transcription factor Gooseberry (Gsb...

...Yu Zhang; Anne Ungar; Catalina Fresquez; Robert Holmgren ABSTRACT Previous studies have shown that the segment polarity locus gooseberry , which contains two closely related transcripts gooseberry-proximal and gooseberry-distal , is required for proper development in both the epidermis...

... within the central nervous system. One of these loci, gooseberry , consists of two divergently transcribed genes, gooseberry and gooseberry neuro , which share a paired box as well as a paired -type homeobox. Here, the expression patterns of the two gooseberry gene products are described in detail...