... niche Gonadogenesis Drosophila Adult stem cells are a crucial component of most organs. Having the unique ability to either self-renew or replace differentiated cells, they function in steady-state homeostasis and can also be activated in response to injury ( Barker et al., 2010...

.... In contrast to a previous report, we did not observe significant conversion of steady-state CySC progeny to hub fate. However, we found that these two cell types derive from a common precursor pool during gonadogenesis. Furthermore, lines mutant embryos exhibited gonads containing excess hub cells, indicating...

... for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 12 1 2011 © 2011. 2011 Drosophila Gonadogenesis Notch Endoderm Niche Interactions of tissue-specific stem cells with their local micro...

... for male gonadogenesis of C. elegans . During the L3 and L4 larval stages of wild-type males, the LC undergoes changes in its position along the migratory route, in transcriptional regulation of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, and in cell morphology. We have identified...

... © 2004. 2004 TRA-1 GLI EHN-3 Cell polarity Cell proliferation Gonadogenesis C. elegans TRA-1 is the single C. elegans homolog of the Ci/GLI family of zinc-finger transcription factors( Zarkower and Hodgkin, 1992 ). In flies and vertebrates, GLI acts in the hedgehog...

...-mail: [email protected] ) * These authors contributed equally to this work 7 5 2004 ©2004. 2004 Pod1 Tcf21 Sf1 Gonadogenesis Testis development Sex reversal Leydig cell Mammalian sexual differentiation is a complex process that begins with the establishment of genetic...

...., Maniwa, R., Nagai, Y., Yamashita, A., Hirose, T., Ishikawa, H. et al. ( 2001 ). PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Genes Cells 6 , 721 -731. Cell polarity Ovulation Gonadogenesis Caenorhabditis...

... fkh-6 reporter is gonad-specific. Genetic and molecular analyses place fkh-6 downstream of tra-1 , the terminal regulator of the global sex determination pathway, with respect to the first gonadal cell division. We conclude that fkh-6 regulates gonadogenesis in both sexes, but is male specific...

...Laura D. Mathies; Samuel T. Henderson; Judith Kimble The C. elegans genome encodes a single Hand bHLH transcription factor. Either hnd-1(RNAi) or a hnd-1 deletion causes partially penetrant defects in viability and gonadogenesis. Dead embryos and young larvae are often misshapen at the posterior...

...Kellee R. Siegfried; Judith Kimble The shape and polarity of the C. elegans gonad is defined during early gonadogenesis by two somatic gonadal precursor cells, Z1 and Z4, and their descendants. Z1 and Z4 divide asymmetrically to establish the proximal-distal axes of the gonad and to generate...

... of Biologists 1998 Caenorhabditis elegans lin-26 Epithelial cell Gonadogenesis Tissue-specific knockout Despite the importance of the somatic gonad to achieve normal reproduction, little is known about its development. In C. elegans , formation of the two-arm hermaphrodite gonad starts...

... they are specified is unknown. Here, we describe a novel regulator of Drosophila gonadogenesis, clift , mutations in which abolish gonad formation. clift is expressed within somatic gonadal precursors as these cells first form, demonstrating that 9-12 cells are selected as somatic gonadal precursors within each...

..., London WC1E 6BT 17 10 1995 © 1995 by Company of Biologists 1995 primordial germ cells cell migration gonadogenesis Drosophila These events were first described by Rabinowitz (1941) and Sonnenblick (1941) . More recently further studies of PGC migration have used...

... – 227 . Oxford: IRL . Wilkins , A. S. ( 1992 ). Origins of the gonadal mesoderm in Drosophila . BioEssays 14 , 627 – 628 . 10.1002/bies.950140910 © 1994 by Company of Biologists 1994 primordial germ cell gonadogenesis mutants cell motility Drosophila...

...H. K. Parmentier; L. P. M. Timmermans ABSTRACT Gonadal development, germ cell differentiation and the appearance of membrane antigenic determinants, specific for male and female germ cells during gonadogenesis, was studied in larval and juvenile carp (Cyprinus carpio L.) until 25 weeks after...