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Keywords: Gonad
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (18): dev199208.
Published: 18 May 2021
...Corey Bunce; Jennifer McKey; Blanche Capel ABSTRACT During development of the mouse urogenital complex, the gonads undergo changes in three-dimensional structure, body position and spatial relationship with the mesonephric ducts, kidneys and adrenals. The complexity of genital ridge development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (11): dev170001.
Published: 10 June 2019
...Nicole Camara; Cale Whitworth; Abigail Dove; Mark Van Doren ABSTRACT Sex-specific development of the gonads is a key aspect of sexual dimorphism that is regulated by Doublesex/Mab3-related transcription factors (DMRTs) in diverse animal species. We find that in mutants for Drosophila dsx...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (12): 2187–2199.
Published: 15 June 2017
... housekeeping function, as well as an extracellular signaling function mediated by the secreted MSPd. Here we show that the C. elegans VAP homolog VPR-1 is essential for gonad development. vpr-1 null mutants are maternal effect sterile due to arrested gonadogenesis following embryo hatching. Somatic gonadal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4461–4472.
Published: 1 December 2012
...Anne-Amandine Chassot; Stephen T. Bradford; Aurélie Auguste; Elodie P. Gregoire; Eric Pailhoux; Dirk G. de Rooij; Andreas Schedl; Marie-Christine Chaboissier The gonad arises from the thickening of the coelomic epithelium and then commits into the sex determination process. Testis differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2283–2287.
Published: 1 July 2012
... indicate that lack of AMH signaling causes the hotei phenotype. BrdU incorporation experiments identified the existence of both quiescent and mitotically active germ cells among the self-renewing, type I population of germ cells in the developing gonad. AMH signaling acts in supporting cells to promote...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (2): 303–312.
Published: 15 January 2010
...Ryuji Hiramatsu; Kyoko Harikae; Naoki Tsunekawa; Masamichi Kurohmaru; Isao Matsuo; Yoshiakira Kanai In mouse embryogenesis, Sry is transiently activated in a center-to-pole wavelike manner along the anteroposterior (AP) axis of developing XY gonads. However, the mechanism and significance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1519–1527.
Published: 15 April 2006
...Leo DiNapoli; Jordan Batchvarov; Blanche Capel In addition to its role in somatic cell development in the testis, our data have revealed a role for Fgf9 in XY germ cell survival. In Fgf9 -null mice, germ cells in the XY gonad decline in numbers after 11.5 days post coitum (dpc), while germ cell...
Journal Articles
Journal: Development
Development (2005) 132 (10): 2415–2423.
Published: 15 May 2005
...Susan Y. Park; Joshua J. Meeks; Gerald Raverot; Liza E. Pfaff; Jeffrey Weiss; Gary D. Hammer; J. Larry Jameson Mutations of orphan nuclear receptors SF1 and DAX1 each cause adrenal insufficiency and gonadal dysgenesis in humans, although the pathological features are distinct. Because Dax1...
Journal Articles
Journal: Development
Development (2004) 131 (15): 3627–3636.
Published: 1 August 2004
... of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate. Between 11.5 dpc and 12.5 dpc, the XY gonad undergoes a rapid increase in width, such that the XY gonad is roughly twice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (6): 1425–1436.
Published: 15 March 2004
..., primary sex determination initially occurs in the gonad, with the sex of other tissues specified as a secondary event. In insects and nematodes, globally acting regulatory pathways have been elucidated, but the more tissue- and organ-specific downstream effectors of these pathways remain largely unknown...
Journal Articles
Journal: Development
Development (2003) 130 (24): 5895–5902.
Published: 15 December 2003
...Humphrey H.-C. Yao; Leo DiNapoli; Blanche Capel The developmental fate of primordial germ cells in the mammalian gonad depends on their environment. In the XY gonad, Sry induces a cascade of molecular and cellular events leading to the organization of testis cords. Germ cells are sequestered inside...
Journal Articles
Journal: Development
Development (2003) 130 (16): 3663–3670.
Published: 15 August 2003
...Katherine Jeays-Ward; Christine Hoyle; Jennifer Brennan; Mathieu Dandonneau; Graham Alldus; Blanche Capel; Amanda Swain The signalling molecule WNT4 has been associated with sex reversal phenotypes in mammals. Here we show that the role of WNT4 in gonad development is to pattern the sex-specific...
Journal Articles
Journal: Development
Development (1986) 98 (1): 269–285.
Published: 1 November 1986
... produced by transplantation of corresponding quail tissue in the region of somites 18–21. A morphometrical analysis of the mesonephric and gonadal area in cross sections shows that the intermediate mesoderm from somites 16 to 23 develops into the mesonephros. A partial agenesis of the mesonephros brought...