...Yujin Zhang; Oliver Lam; Minh-Thanh T. Nguyen; Gracia Ng; Warren S. Pear; Walden Ai; I-Jong Wang; Winston W.-Y. Kao; Chia-Yang Liu Conjunctival goblet cells primarily synthesize mucins to lubricate the ocular surface, which is essential for normal vision. Notch signaling has been known to associate...

... epithelial cell fate and regeneration by directly restricting the goblet cell lineage program. Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior...

... in the gastrointestinal tract has not been investigated. To address this issue, we have generated Klf4 –/– mice by homologous recombination in embryonic stem cells. In this study, we provide the first in vivo evidence that Klf4 is a goblet cell-specific differentiation factor in the colon. Klf4 –/– mice exhibit normal...