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Keywords: Glypican
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Journal Articles
Journal: Development
Development (2013) 140 (1): 107–116.
Published: 01 January 2013
... glypican heparan sulfate proteoglycans (HSPGs) and the secreted protein Shifted (Shf), a member of Wnt inhibitory factor 1 (WIF1) family. The glypicans and Shf are required for long-range Hh movement and signaling; it has been proposed that Shf promotes long-range Hh signaling by reinforcing binding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (12): 2033–2044.
Published: 15 June 2010
... superfamily member Interference hedgehog (Ihog) and Dally-like (Dlp), a glypican that comprises a core protein and heparan sulfate glycosaminoglycan (GAG) chains. Here, we show in Drosophila that the Dlp core protein can interact with Hh and is essential for its function in Hh signaling. In wing discs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3627–3635.
Published: 01 November 2009
... molecules in the ovarian niche specify GSC fate at single-cell resolution. How this steep gradient of BMP response is achieved remains elusive. In this study, we found that the glypican Dally is essential for maintaining GSC identity. Dally is highly expressed in cap cells. Cell-specific Dally-RNAi, mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (3): 601–611.
Published: 01 February 2004
... across receiving cells. However, the molecular mechanism of Ttv- mediated Hh movement is poorly defined. We show that Dally and Dally-like (Dly), two Drosophila glypican members of the heparan sulphate proteoglycan (HSPG) family, are the substrates of Ttv and are essential for Hh movement. We show that...