....2007.03086.x Plaxton , W. C. (1996). The organization and regulation of plant glycolysis . Annu. Rev. Plant Physiol. Plant Mol. Biol. 47 , 185 - 214 . 10.1146/annurev.arplant.47.1.185 Proietti , S. , Paradiso , R. , Moscatello , S. , Saccardo , F...

... systems reveal defects in early neurogenesis due to dysregulation of key metabolic pathways associated with Leigh syndrome. Leigh syndrome Stem cells Glycolysis Oxidative phosphorylation Mitochondria Neural precursor cells Neural rosettes Brain organoids National Institutes of Health...

...Ke Zhao; Xinyi Huang; Wukui Zhao; Bin Lu; Zhongzhou Yang ABSTRACT The mitochondrial matrix AAA + Lon protease (LONP1) degrades misfolded or unassembled proteins, which play a pivotal role in mitochondrial quality control. During heart development, a metabolic shift from anaerobic glycolysis...

... stage of forebrain specification. Progenitors showed striking mitochondrial structural changes transitioning from glycolytic cristae at E8.5, to more traditional mitochondria at E10.5. Accordingly, glucose use shifted in progenitors such that E8.5 progenitors relied on glycolysis, and after NTC...

... that heightened glycolytic metabolism is acquired, indicating that metabolic modulation of both glycolysis and mitochondrial metabolism occurs during exit from pluripotency in hPSCs. * Author for correspondence ([email protected]) Competing interests The authors declare no competing...

... controls AKT signaling in gastrulas and glycolysis rate in adult cells. Here, we focus on PFKFB4 function in NC during and after neurulation, using time-controlled or hypomorph depletions in vivo . We find that PFKFB4 is essential both for specification of functional premigratory NC and for its migration...

...Koji Sugiura; You-Qiang Su; Francisco J. Diaz; Stephanie A. Pangas; Shweta Sharma; Karen Wigglesworth; Marilyn J. O'Brien; Martin M. Matzuk; Shunichi Shimasaki; John J. Eppig Mammalian oocytes are deficient in their ability to carry out glycolysis. Therefore, the products of glycolysis...