... remains unclear. Here, we show that glycogen metabolism is regulated in a tissue-specific manner under starvation conditions in the fruit fly Drosophila . The mobilization of fat body glycogen in larvae is independent of Adipokinetic hormone (Akh, the glucagon homolog) but is regulated by sugar...

... of contextual regulators of cell fate acquisition and maintenance. In murine models of diabetes, glucagon-secreting alpha cells transdifferentiate into insulin-secreting beta cells following targeted beta cell depletion, regenerating the form and function of the pancreatic islet. However, the molecular triggers...

... and implies that both Nkx6.1 and Nkx6.2 possess alpha- and beta-cell-specifying activities. * Author for correspondence (e-mail: [email protected] ) 28 4 2007 © 2007. 2007 Nkx6.1 Nkx6.2 Pdx1 Ngn3 Pancreas Islet Endocrine Insulin Glucagon Development Mouse Transgenic...

... factor MYT1 as a co-factor. Expression of a dominant-negative form of Myt1 (DnMYT1) reduces the ability of NGN3 to induce ectopic glucagon expression from chicken endoderm ( Gu et al.,2004 ). Moreover, inhibition of MYT1 activity in endocrine progenitors by DnMYT1 in transgenic mice results in a severe...

... but do not arise from the neurectoderm . Dev. Biol . 142 , 368 – 379 . 10.1016/0012-1606(90)90357-O Teitelman , G. and Lee , J. K. ( 1987 ). Cell lineage analysis of pancreatic islet cell development: glucagon and insulin cells arise from catecholaminergic precursors present...

... of human fetal pancreas. * Author for correspondence 13 12 1992 © 1992 by Company of Biologists 1992 β -cell development EGF-R fetal glucagon insulin pancreas somatostatin TGF- α Transforming growth factor alpha (TGF- α ) is a mitogenic 50 amino acid polypeptide...