... end. In order to filter the blood and produce urine, specialized structures are formed at specific proximal-distal locations along the nephron, including the glomerulus at the proximal end, the tubule in the middle and the collecting duct at the distal end. The developmental processes that specify...

...Jeffrey T. White; Bo Zhang; Débora M. Cerqueira; Uyen Tran; Oliver Wessely Podocytes are highly specialized cells in the vertebrate kidney. They participate in the formation of the size-exclusion barrier of the glomerulus/glomus and recruit mesangial and endothelial cells to form a mature...

... failed to coalesce into a compact structure at the midline, and a mature vascularized glomerulus is never formed. nephrin is an essential component of the pronephric glomerulus and is expressed in podocytes in wild-type embryos ( Fig. 4G )( Kramer-Zucker et al., 2005 ). osr1 loss of function...

[email protected] ) * Present address: Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA † Present address: Department of Biology, Williams College, Williamstown, MA 01267, USA 14 1 2005 ©2005. 2005 Axon guidance Pioneer neurons Glomerulus Transgenic zebrafish...

... functions and is organized into discrete segments: glomerulus, tubules and nephric duct. The site of origin of these cells is poorly understood, as are their lineage relationships. We have defined regions of the intermediate mesoderm as candidates for the pronephric field by expression patterns of the Wilms...