...Tim J. Yeung; David G. Wilkinson ABSTRACT In the vertebrate nervous system, neurogenesis generally precedes gliogenesis. The mechanisms driving the switch in cell type production and generation of the correct proportion of cell types remain unclear. Here, we show that Fgf20 signalling patterns...

... involved in gliogenesis and is required for Müller glia production. We report that Ikzf4 regulates Notch signaling genes and is sufficient to activate the Hes1 promoter through two Ikzf GGAA-binding motifs, suggesting a mechanism by which Ikzf4 may influence gliogenesis. These results uncover...

... heterogeneity remains unclear. Here, we have dissected subpopulations of embryonic mouse forebrain progenitors using single-cell transcriptome analyses. Our sequencing data revealed two molecularly distinct APC subgroups at the start of gliogenesis from both dorsal and ventral forebrains. The two APC subgroups...

.... This raises an interesting possibility that glial precursors with distinct developmental fates exist that govern region-specific gliogenesis. Here, we have mapped the glial progeny produced by the Drosophila type II neuroblasts, which, like vertebrate radial glia cells, yield both neurons and glia via...

... factor essential for specification and differentiation of retinal Müller glia, also plays a crucial role in the development of retinal neurons. Overexpression of Lhx2 with its transcriptional co-activator Ldb1 triggers cell cycle exit and inhibits both Notch signaling and retinal gliogenesis. Lhx2 / Ldb1...

.... Previously, we found that the Hes genes inhibit neuronal differentiation and maintain NSCs. Here, we generated transgenic mice that overexpress Hes5 in NSCs of the central nervous system, and found that the transition timing from deep to superficial layer neurogenesis was shifted earlier, while gliogenesis...

... to increased progenitor cell numbers and affects cell fate choice in the developing mouse olfactory epithelium. Neurogenesis Gliogenesis Cellular differentiation Neogenin Olfactory epithelium RGM Mouse Organogenesis relies on the production of distinct cell types from stem/progenitor cells...

... foetal development. However, the molecular cues that instruct gliogenesis and determine glial cell type are poorly understood. During post-embryonic development, the number of glia in the Drosophila larval brain increases dramatically, potentially providing a powerful model for understanding gliogenesis...

... ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 12 10 2011 © 2011. Spinal cord Gliogenesis Tenascin C Extracellular matrix Growth factor responsiveness Neural patterning Astrocytes...

... interests. 23 8 2011 © 2011. Hand2 ENS Neurogenesis Gliogenesis Neural precursor cell Neurotransmitter specification The enteric nervous system (ENS) comprises a network of neural crest-derived neurons that express a diverse array of neurotransmitters...

..., and not gliogenesis, in OE development, consistent with an inhibitory effect of FST on GDF11 function. To analyze ASCL1 + progenitors, 8-hour OE explants were prepared from CD-1 embryos, ASCL1 + IF performed and cells quantified as described ( Gordon et al., 1995 ). To assess effects on INPs, explants...

... © 2010. 2010 FGF Sox9 Olig2 Radial glia Neural progenitor Astroglia Astrocyte Oligodendrocyte Somatic motoneuron Gliogenesis Neurogenesis Patterning Positional identity Zebrafish References Amoyel M. , Cheng Y. C. , Jiang Y. J. , Wilkinson D. G...

.... Barnabé-Heider, F., Wasylnka, J. A., Fernandes, K. J. L.,Porsche, C., Sendtner, M., Kaplan, D. R. and Miller, F. D. ( 2005 ). Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1. Neuron 48 , 253 -265. Behar, T. N., Dugich-Djordjevic, M. M., Li, Y.-X., Ma...

...Merritt K. Taylor; Kelly Yeager; Sean J. Morrison Constitutive activation of the Notch pathway can promote gliogenesis by peripheral (PNS) and central (CNS) nervous system progenitors. This raises the question of whether physiological Notch signaling regulates gliogenesis in vivo. To test this, we...

... in Xenopus,XHes2 , as a regulator to bias retinal precursor cells towards a glial fate. XHes2 expression is predominantly restricted to sensory organ territories, including the retina. Using in vivo lipofection in the optic vesicle, we found that XHes2 overexpression dramatically increases gliogenesis...

... expression within the neuroepithelium at stages during which neurogenesis occurs (E14.5,not shown) and also within the SVZ at later stages during which gliogenesis occurs (E17.5) ( Fig. 1A,B ). Fig. 1. Expression of tenascin C (TNC) in subventricular zone (SVZ) cells revealed by lacZ expression...

.... A recent report showed that in the adult bristle lineage, gcm expression is negatively regulated by Notch signaling ( Van De Bor, V. and Giangrande, A. ( 2001 ). Development 128 , 1381 -1390 ). Here we show that the effect of Notch activation on gliogenesis is context-dependent. In the dorsal bipolar...

[email protected] ) 21 2 2002 © 2002. 2002 Neurogenesis Gliogenesis Cell cycle regulation Notch Proneural gene Xenopus laevis Xath5 In the central nervous system, neurons and glia often differentiate in a conserved histogenic order. In the Xenopus retina, for example, retinal...

..., according to our in vitro experiments, we might possibly expect increased neurogenesis to occur at the expense of gliogenesis in peripheral ganglia of Sox10 +/– embryos. There is ample evidence that the regulation of the correct neuronal cell number involves programmed cell death both in a target...

.... Badenhorst, P., Harrison, S. and Travers, A. A. ( 1996 ). End of the line? Tramtrack and cell fate determination in Drosophila . Genes Cells 1 , 707 -716. Bernardoni, R., Kammerer, M., Vonesch, J. L. and Giangrande, A. ( 1999 ). Gliogenesis depends on glide/gcm through asymmetric division...