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Keywords: Gli
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Journal Articles
Journal: Development
Development (2018) 145 (13): dev159947.
Published: 09 July 2018
... and GLI3 in cortical stromal cells that control nephron formation via TGFβ signaling. GLI Hedgehog Stroma Nephron Mouse Crosstalk TGFβ The mammalian kidney contains hundreds of thousands of nephrons that each connect to a collecting system composed of collecting ducts, calyces...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3944–3955.
Published: 01 November 2016
...Zhigang Jin; Tyler Schwend; Jia Fu; Zehua Bao; Jing Liang; Huimin Zhao; Wenyan Mei; Jing Yang Hedgehog (Hh) signaling is fundamentally important for development and adult tissue homeostasis. It is well established that in vertebrates Sufu directly binds and inhibits Gli proteins, the downstream...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3868–3878.
Published: 15 October 2014
... that accurately predicts tissue patterning. The analysis indicates that, for each target gene regulated by Gli, which is the transcriptional effector of Shh signalling, there is a neutral point in the gradient, either side of which altering the Gli binding affinity has opposite effects on gene expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1906–1914.
Published: 01 May 2014
...Qiang Li; Jordan P. Lewandowski; Marian B. Powell; Jacqueline L. Norrie; Seung Hee Cho; Steven A. Vokes The transcriptional response to the Hedgehog (Hh) pathway is mediated by Gli proteins, which function as context-dependent transcriptional activators or repressors. However, the mechanism...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1740–1750.
Published: 15 April 2013
... development. Using Tg(GBS-GFP) mice as a reporter of Shh-dependent Gli activity, we provide evidence of a decreasing medial-to-lateral gradient of Shh activity in the sclerotome. A similar gradient is formed in the ventral neural tube ( Balaskas et al., 2012 ; Chamberlain et al., 2008 ), which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2533–2542.
Published: 15 June 2011
...Steven A. Marks; Daniel Kalderon Hedgehog (Hh) signaling activates full-length Ci/Gli family transcription factors and prevents Ci/Gli proteolytic processing to repressor forms. In the absence of Hh, Ci/Gli processing is initiated by direct Pka phosphorylation. Despite those fundamental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 755–765.
Published: 15 February 2011
..., to limit its expression to MPs and MFFs. We suggest a novel basis for crosstalk between the Hh and BMP pathways, whereby BMP-mediated repression of Hh target genes is promoted by a direct interaction between Smads and truncated Glis, an interaction that is abrogated by Hh induced depletion of the latter...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 4051–4060.
Published: 01 December 2010
... ). Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression . Development 135 , 237 - 247 . Ang S. L. , Rossant J. ( 1994 ). HNF-3 beta is essential for node and notochord formation in mouse development . Cell 78 , 561 - 574...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (18): 3089–3098.
Published: 15 September 2009
... and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube. Gene Expr. Patterns 7 , 596 -605. Han, Y. G., Kwok, B. H. and Kernan, M. J. ( 2003 ). Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 665–676.
Published: 15 February 2009
..., CNRS URA 2578,Pasteur Institute, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France 24 11 2008 © 2009. 2009 Retinoids Gastrulation Neurogenesis Spinal cord Somites Sonic hedgehog Gli Fibroblast growth factor Mouse In the vertebrate embryo, the trunk structures (spinal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3325–3331.
Published: 15 October 2008
....). References Altmann, C. R. and Brivanlou, A. H. ( 2001 ). Neural patterning in the vertebrate embryo. Int. Rev. Cytol. 203 , 447 -482. Alvarez-Medina, R., Cayuso, J., Okubo, T. and Marti, E. ( 2008 ). Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3...
Journal Articles
Journal: Development
Development (2007) 134 (10): 1977–1989.
Published: 15 May 2007
... a Gli-mediated(Gli1-3) transcriptional network. Identifying Gli targets in a systematic fashion is central to the understanding of the action of Shh. We examined this issue in differentiating neural progenitors in mouse. An epitope-tagged Gli-activator protein was used to directly isolate cis-regulatory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (9): 1713–1722.
Published: 01 May 2007
... of mutant alleles for Shh, Gli2 and Gli3 . Our study shows that Gli3 repressor(R) is required for patterning dorsal inner ear structures, whereas Gli activator (A) proteins are essential for ventral inner ear structures. A proper balance of Gli3R and Gli2/3A is required along the length of the dorsoventral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 525–533.
Published: 01 February 2007
... of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 437 , 894 -897. Bai, C. B., Stephen, D. and Joyner, A. L. ( 2004 ). All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6 , 103 -115. Baskin, L. S...
Journal Articles
Journal: Development
Development (2006) 133 (18): 3661–3670.
Published: 15 September 2006
... 2006 © 2006. 2006 Mammary Breast Gli Hedgehog Wnt The Hedgehog (Hh) family of secreted morphogens controls the patterning,growth, morphogenesis and homeostasis of many tissues, including vertebrate and invertebrate epidermal appendages( Ingham and McMahon, 2001 ). The Hh pathway...
Journal Articles
Journal: Development
Development (2006) 133 (18): 3723–3732.
Published: 15 September 2006
... spatiotemporal expression of Myf5 in the epaxial domain of the somite, mediating the synergistic action of the Wnt/β-catenin and the Shh/Gli pathways. Taken together, these results demonstrate that Myf5 is a direct target of Wnt/β-catenin, and that its full activation requires a cooperative interaction between...
Journal Articles
Journal: Development
Development (2006) 133 (10): 2001–2010.
Published: 15 May 2006
... responses in humans. * Author for correspondence (e-mail: joan.hooper@uchsc.edu ) 17 3 2006 © 2006. 2006 Hedgehog signaling Gli E3 ubiquitin ligase Cubitus interruptus Roadkill Drosophila Hedgehog (Hh) signaling is a phylogenetically conserved pathway...
Journal Articles
Journal: Development
Development (2005) 132 (14): 3267–3279.
Published: 15 July 2005
...Vân Nguyen; Ann L. Chokas; Barbara Stecca; Ariel Ruiz i Altaba The Gli proteins are critical components of multiple processes in development, homeostasis and disease, including neurogenesis and tumorigenesis. However, it is unclear how the Gli code, the sum of their combinatorial positive...
Journal Articles
Journal: Development
Development (2005) 132 (13): 3103–3111.
Published: 01 July 2005
... and upstream of the Gli transcription factors,the mechanism by which IFT regulates Gli function is unknown. The developing limb provides an excellent system to study Hh signaling, in particular as it allows a biological and molecular readout of both Gli activator and repressor function. Here we report...
Journal Articles
Journal: Development
Development (2005) 132 (2): 335–344.
Published: 15 January 2005
....,2003 ), it regulates cell proliferation in the subgranular layer( Lai et al., 2003 ; Machold et al., 2003 ), and is also involved in the control of stem cell behavior in the developing neocortex( Palma and Ruiz i Altaba,2004 ). Shh-Gli signaling may thus be a general mechanism for the regulation...