...Maggie S. Matern; Beatrice Milon; Erika L. Lipford; Mark McMurray; Yoko Ogawa; Andrew Tkaczuk; Yang Song; Ran Elkon; Ronna Hertzano ABSTRACT Despite the known importance of the transcription factors ATOH1, POU4F3 and GFI1 in hair cell development and regeneration, their downstream transcriptional...

... and differentiation is crucial not only to understand inner ear development but also to improve cell replacement therapies for hearing disorders. Here, we show that combined expression of the transcription factors Gfi1, Pou4f3 and Atoh1 can induce direct programming towards HC fate, both during in vitro mouse...

... factor Prospero (Pros). Here, we report that Senseless (Sens), a Drosophila ortholog of the vertebrate Gfi1 transcription factor, plays an opposing role to Pros by both negatively regulating R7-based features and positively enforcing R8-based features during terminal differentiation. In addition, we...

...Deeann Wallis; Melanie Hamblen; Yi Zhou; Koen J. T. Venken; Armin Schumacher; H. Leighton Grimes; Huda Y. Zoghbi; Stuart H. Orkin; Hugo J. Bellen Gfi1 was first identified as causing interleukin 2-independent growth in T cells and lymphomagenesis in mice. Much work has shown that Gfi1 and Gfi1b...