... germ cells, the testis-specific PHF7 protein acts as an oncogene with transcriptional reprogramming activity that inappropriately activates male germ cell genes. Germ cell fate Oogenesis Germline tumors Sex determination Germ cell development culminates in the production of sexually...

... preventing the risk of tumor formation. Sxl Oogenesis Germline tumors Jak/Stat Phf7 Homeostasis of adult tissues depends on a stable population of stem cells that have the capacity to give rise to both self-renewing and differentiating daughter cells. Many cancers exhibit stem cell-like...