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Keywords: Germline stem cells
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Journal Articles
Journal: Development
Development (2022) 149 (3): dev199890.
Published: 4 February 2022
...-regulatory element of the gene brinker regulates distal enhancer action and also directly acts to control brinker expression levels in cells co-expressing BMP ligand thereby influencing germ cell homeostasis. brinker Promoter-proximal element BMP signaling Oogenesis Niche Germline stem cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199716.
Published: 17 September 2021
...Gema Villa-Fombuena; María Lobo-Pecellín; Miriam Marín-Menguiano; Patricia Rojas-Ríos; Acaimo González-Reyes ABSTRACT Drosophila female germline stem cells (GSCs) are found inside the cellular niche at the tip of the ovary. They undergo asymmetric divisions to renew the stem cell lineage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev196345.
Published: 2 August 2021
...Kumari Pushpa; Sunayana Dagar; Harsh Kumar; Diksha Pathak; Sivaram V. S. Mylavarapu ABSTRACT The conserved exocyst complex regulates plasma membrane-directed vesicle fusion in eukaryotes. However, its role in stem cell proliferation has not been reported. Germline stem cell (GSC) proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev187773.
Published: 15 April 2021
...Sylvain Bertho; Mara Clapp; Torsten U. Banisch; Jan Bandemer; Erez Raz; Florence L. Marlow ABSTRACT Fertility and gamete reserves are maintained by asymmetric divisions of the germline stem cells to produce new stem cells or daughters that differentiate as gametes. Before entering meiosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev186171.
Published: 13 May 2020
... . Mol. Biol. Cell   25 , 1127 - 1136 . 10.1091/mbc.e13-08-0477 Barton , L. J. , Pinto , B. S. , Wallrath , L. L. and Geyer , P. K. ( 2013 ). The Drosophila nuclear lamina protein otefin is required for germline stem cell survival . Dev. Cell   25 , 645 - 654 . 10.1016...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
.... Drosophila Niche Germline stem cells Somatic stem cells Testis Intestine Intestinal stem cells Enterocytes Wing disc Cytokines Proliferation Survival Differentiation Cell competition Niche competition Inflammation Regeneration Cellular plasticity Cell reprogramming In the early...
Journal Articles
Journal: Development
Development (2018) 145 (17): dev161786.
Published: 7 September 2018
...: A role for Piwi-interacting RNAs (piRNAs) in the regulation of endogenous gene expression challenges dogma in the piRNA field. This Review focuses on recent data addressing the biological and developmental functions of piRNAs. Drosophila embryonic patterning Germ cells Germline stem cells...
Journal Articles
Journal: Development
Development (2018) 145 (3): dev158527.
Published: 7 February 2018
...Xiaoxi Wang; Andrea Page-McCaw ABSTRACT Stem cells reside in a niche, a local environment whose cellular and molecular complexity is still being elucidated. In Drosophila ovaries, germline stem cells depend on cap cells for self-renewing signals and physical attachment. Germline stem cells also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3224–3231.
Published: 15 September 2017
...Lichao Luo; Chia Keng Siah; Yu Cai Homeostasis of adult tissues is maintained by a small number of stem cells, which are sustained by their niches. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC self-renewal. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 1937–1947.
Published: 1 June 2017
...Torsten U. Banisch; Iris Maimon; Tali Dadosh; Lilach Gilboa Two different compartments support germline stem cell (GSC) self-renewal and their timely differentiation: the classical niche provides maintenance cues, while a differentiation compartment, formed by somatic escort cells (ECs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2930–2945.
Published: 15 August 2016
... and identified 221 genes required for germline stem cell (GSC) maintenance or differentiation. Knockdown of these genes in transit-amplifying spermatogonia and cyst cells further revealed various phenotypes. Complex analysis uncovered that many of the identified genes are involved in key steps of protein...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4230–4241.
Published: 15 December 2015
.... In adults, however, differentiated stem cell progeny requirements are generally reduced and vary according to the spatiotemporal needs of each tissue. We demonstrate here that differential regulation of germline stem cell proliferation rates in Caenorhabditis elegans adults is accomplished through localized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 883–892.
Published: 1 March 2015
... , somatic precursors for niches, and germ cells that will become germline stem cells, co-develop. Somatic precursors proliferate during the first 3 days of larval development. By mid-third instar, adult terminal filament (TF) (part of the germline stem cell niche) cells first appear, and differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4479–4488.
Published: 1 December 2014
... are influenced by whole-body physiology through multiple diet-dependent factors. For example, nutrient-dependent pathways acting within the Drosophila ovary control the number and proliferation of germline stem cells (GSCs). The potential role of nutrient sensing by adipocytes in modulating stem cells in other...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 259–268.
Published: 15 January 2014
... fully rescues the Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2. The piRNA pathway is essential in early oogenesis, and we find that nuclear localization of Zfrp8 in germline stem cells and their offspring is regulated by some piRNA pathway genes. We also show that Zfrp8 forms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3732–3740.
Published: 15 October 2012
... component PGL-1. PGL-1 is required to localize FBF-2 to perinuclear P granules and for efficient binding of FBF-2 to its mRNA targets. We conclude that multiple regulatory mechanisms converge on meiotic RNAs to ensure silencing in germline stem cells. Our findings also support the view that P granules...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3357–3366.
Published: 15 August 2011
...Abbie L. Casper; Kelly Baxter; Mark Van Doren Male and female germ cells follow distinct developmental paths with respect to germline stem cell (GSC) production and the types of differentiated progeny they produce (sperm versus egg). An essential aspect of germline development is how sexual...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 533–540.
Published: 1 February 2008
... stem cell maintenance remain largely unknown. Here we demonstrate that removal of the Jak/Stat pathway in support cells of the Drosophila ovarian niche leads to germline stem cell loss by differentiation. Conversely,ectopic Jak/Stat activation in support cells induces stem cell tumours,implying...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (24): 5365–5374.
Published: 15 December 2005
...Rongwen Xi; Choung Doan; Dazhi Liu; Ting Xie In the Drosophila ovary, germline stem cell (GSC) self-renewal is controlled by both extrinsic and intrinsic factors. The Bmp signal from niche cells controls GSC self-renewal by directly repressing a Bam-dependent differentiation pathway in GSCs. pelota...