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Keywords: Germline stem cells
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Journal Articles
Journal: Development
Development dev.199890.
Published: 17 January 2022
... Oogenesis Niche Germline stem cells Undifferentiated germ cells Drosophila melanogaster National Institues of Health R03HD101961 brinker levels regulated by a promoter proximal element support germ cell homeostasis Leslie Dunipace#, Susan Newcomb#, Angelike Stathopoulos* Division...
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199716.
Published: 17 September 2021
...Gema Villa-Fombuena; María Lobo-Pecellín; Miriam Marín-Menguiano; Patricia Rojas-Ríos; Acaimo González-Reyes ABSTRACT Drosophila female germline stem cells (GSCs) are found inside the cellular niche at the tip of the ovary. They undergo asymmetric divisions to renew the stem cell lineage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev196345.
Published: 02 August 2021
...Kumari Pushpa; Sunayana Dagar; Harsh Kumar; Diksha Pathak; Sivaram V. S. Mylavarapu ABSTRACT The conserved exocyst complex regulates plasma membrane-directed vesicle fusion in eukaryotes. However, its role in stem cell proliferation has not been reported. Germline stem cell (GSC) proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev187773.
Published: 15 April 2021
...Sylvain Bertho; Mara Clapp; Torsten U. Banisch; Jan Bandemer; Erez Raz; Florence L. Marlow ABSTRACT Fertility and gamete reserves are maintained by asymmetric divisions of the germline stem cells to produce new stem cells or daughters that differentiate as gametes. Before entering meiosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev186171.
Published: 13 May 2020
... that contributes to stem cell maintenance. Nuclear lamina LEM-domain proteins Drosophila oogenesis Germline stem cells Barrier-to-autointegration factor Checkpoint kinase 2 Chk2 The nuclear lamina (NL) is an extensive protein network that underlies the inner nuclear membrane. Comprising...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... the similarities between Drosophila and vertebrates. Drosophila Niche Germline stem cells Somatic stem cells Testis Intestine Intestinal stem cells Enterocytes Wing disc Cytokines Proliferation Survival Differentiation Cell competition Niche competition Inflammation Regeneration Cellular...
Journal Articles
Journal: Development
Development (2018) 145 (17): dev161786.
Published: 07 September 2018
... genes defined by piwi are essential for stem cell self-renewal . Genes Dev.   12 , 3715 - 3727 . 10.1101/gad.12.23.3715 Cox , D. N. , Chao , A. and Lin , H. ( 2000 ). piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells...
Journal Articles
Journal: Development
Development (2018) 145 (3): dev158527.
Published: 07 February 2018
...Xiaoxi Wang; Andrea Page-McCaw ABSTRACT Stem cells reside in a niche, a local environment whose cellular and molecular complexity is still being elucidated. In Drosophila ovaries, germline stem cells depend on cap cells for self-renewing signals and physical attachment. Germline stem cells also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3224–3231.
Published: 15 September 2017
...Lichao Luo; Chia Keng Siah; Yu Cai Homeostasis of adult tissues is maintained by a small number of stem cells, which are sustained by their niches. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC self-renewal. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 1937–1947.
Published: 01 June 2017
...Torsten U. Banisch; Iris Maimon; Tali Dadosh; Lilach Gilboa Two different compartments support germline stem cell (GSC) self-renewal and their timely differentiation: the classical niche provides maintenance cues, while a differentiation compartment, formed by somatic escort cells (ECs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2930–2945.
Published: 15 August 2016
... and identified 221 genes required for germline stem cell (GSC) maintenance or differentiation. Knockdown of these genes in transit-amplifying spermatogonia and cyst cells further revealed various phenotypes. Complex analysis uncovered that many of the identified genes are involved in key steps of protein...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4230–4241.
Published: 15 December 2015
.... In adults, however, differentiated stem cell progeny requirements are generally reduced and vary according to the spatiotemporal needs of each tissue. We demonstrate here that differential regulation of germline stem cell proliferation rates in Caenorhabditis elegans adults is accomplished through localized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 883–892.
Published: 01 March 2015
... , somatic precursors for niches, and germ cells that will become germline stem cells, co-develop. Somatic precursors proliferate during the first 3 days of larval development. By mid-third instar, adult terminal filament (TF) (part of the germline stem cell niche) cells first appear, and differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4479–4488.
Published: 01 December 2014
... are influenced by whole-body physiology through multiple diet-dependent factors. For example, nutrient-dependent pathways acting within the Drosophila ovary control the number and proliferation of germline stem cells (GSCs). The potential role of nutrient sensing by adipocytes in modulating stem cells in other...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 259–268.
Published: 15 January 2014
... fully rescues the Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2. The piRNA pathway is essential in early oogenesis, and we find that nuclear localization of Zfrp8 in germline stem cells and their offspring is regulated by some piRNA pathway genes. We also show that Zfrp8 forms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3732–3740.
Published: 15 October 2012
... component PGL-1. PGL-1 is required to localize FBF-2 to perinuclear P granules and for efficient binding of FBF-2 to its mRNA targets. We conclude that multiple regulatory mechanisms converge on meiotic RNAs to ensure silencing in germline stem cells. Our findings also support the view that P granules...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3357–3366.
Published: 15 August 2011
...Abbie L. Casper; Kelly Baxter; Mark Van Doren Male and female germ cells follow distinct developmental paths with respect to germline stem cell (GSC) production and the types of differentiated progeny they produce (sperm versus egg). An essential aspect of germline development is how sexual...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 533–540.
Published: 01 February 2008
... stem cell maintenance remain largely unknown. Here we demonstrate that removal of the Jak/Stat pathway in support cells of the Drosophila ovarian niche leads to germline stem cell loss by differentiation. Conversely,ectopic Jak/Stat activation in support cells induces stem cell tumours,implying...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (24): 5365–5374.
Published: 15 December 2005
...Rongwen Xi; Choung Doan; Dazhi Liu; Ting Xie In the Drosophila ovary, germline stem cell (GSC) self-renewal is controlled by both extrinsic and intrinsic factors. The Bmp signal from niche cells controls GSC self-renewal by directly repressing a Bam-dependent differentiation pathway in GSCs. pelota...