.... Biol. 400 , 258 - 265 . 10.1016/j.ydbio.2015.02.004 Chen , D. and McKearin , D. M. ( 2003 ). A discrete transcriptional silencer in the bam gene determines asymmetric division of the Drosophila germline stem cell . Development 130 , 1159 - 1170 . 10.1242/dev.00325...

...Gema Villa-Fombuena; María Lobo-Pecellín; Miriam Marín-Menguiano; Patricia Rojas-Ríos; Acaimo González-Reyes ABSTRACT Drosophila female germline stem cells (GSCs) are found inside the cellular niche at the tip of the ovary. They undergo asymmetric divisions to renew the stem cell lineage...

...Kumari Pushpa; Sunayana Dagar; Harsh Kumar; Diksha Pathak; Sivaram V. S. Mylavarapu ABSTRACT The conserved exocyst complex regulates plasma membrane-directed vesicle fusion in eukaryotes. However, its role in stem cell proliferation has not been reported. Germline stem cell (GSC) proliferation...

...Sylvain Bertho; Mara Clapp; Torsten U. Banisch; Jan Bandemer; Erez Raz; Florence L. Marlow ABSTRACT Fertility and gamete reserves are maintained by asymmetric divisions of the germline stem cells to produce new stem cells or daughters that differentiate as gametes. Before entering meiosis...

.... Cell   25 , 1127 - 1136 . 10.1091/mbc.e13-08-0477 Barton , L. J. , Pinto , B. S. , Wallrath , L. L. and Geyer , P. K. ( 2013 ). The Drosophila nuclear lamina protein otefin is required for germline stem cell survival . Dev. Cell   25 , 645 - 654 . 10.1016/j.devcel...

... Niche Germline stem cells Somatic stem cells Testis Intestine Intestinal stem cells Enterocytes Wing disc Cytokines Proliferation Survival Differentiation Cell competition Niche competition Inflammation Regeneration Cellular plasticity Cell reprogramming In the early 1990s...

... a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells . Development   127 , 503 - 514 . Czech , B. , Preall , J. B. , McGinn , J. and Hannon , G. J. ( 2013 ). A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors...

...Xiaoxi Wang; Andrea Page-McCaw ABSTRACT Stem cells reside in a niche, a local environment whose cellular and molecular complexity is still being elucidated. In Drosophila ovaries, germline stem cells depend on cap cells for self-renewing signals and physical attachment. Germline stem cells also...

...Lichao Luo; Chia Keng Siah; Yu Cai Homeostasis of adult tissues is maintained by a small number of stem cells, which are sustained by their niches. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC self-renewal. However...

...Torsten U. Banisch; Iris Maimon; Tali Dadosh; Lilach Gilboa Two different compartments support germline stem cell (GSC) self-renewal and their timely differentiation: the classical niche provides maintenance cues, while a differentiation compartment, formed by somatic escort cells (ECs...

... and identified 221 genes required for germline stem cell (GSC) maintenance or differentiation. Knockdown of these genes in transit-amplifying spermatogonia and cyst cells further revealed various phenotypes. Complex analysis uncovered that many of the identified genes are involved in key steps of protein...

.... In adults, however, differentiated stem cell progeny requirements are generally reduced and vary according to the spatiotemporal needs of each tissue. We demonstrate here that differential regulation of germline stem cell proliferation rates in Caenorhabditis elegans adults is accomplished through localized...

... , somatic precursors for niches, and germ cells that will become germline stem cells, co-develop. Somatic precursors proliferate during the first 3 days of larval development. By mid-third instar, adult terminal filament (TF) (part of the germline stem cell niche) cells first appear, and differentiation...

... are influenced by whole-body physiology through multiple diet-dependent factors. For example, nutrient-dependent pathways acting within the Drosophila ovary control the number and proliferation of germline stem cells (GSCs). The potential role of nutrient sensing by adipocytes in modulating stem cells in other...

... fully rescues the Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2. The piRNA pathway is essential in early oogenesis, and we find that nuclear localization of Zfrp8 in germline stem cells and their offspring is regulated by some piRNA pathway genes. We also show that Zfrp8 forms...

... component PGL-1. PGL-1 is required to localize FBF-2 to perinuclear P granules and for efficient binding of FBF-2 to its mRNA targets. We conclude that multiple regulatory mechanisms converge on meiotic RNAs to ensure silencing in germline stem cells. Our findings also support the view that P granules...

...Abbie L. Casper; Kelly Baxter; Mark Van Doren Male and female germ cells follow distinct developmental paths with respect to germline stem cell (GSC) production and the types of differentiated progeny they produce (sperm versus egg). An essential aspect of germline development is how sexual...

... stem cell maintenance remain largely unknown. Here we demonstrate that removal of the Jak/Stat pathway in support cells of the Drosophila ovarian niche leads to germline stem cell loss by differentiation. Conversely,ectopic Jak/Stat activation in support cells induces stem cell tumours,implying...

...Rongwen Xi; Choung Doan; Dazhi Liu; Ting Xie In the Drosophila ovary, germline stem cell (GSC) self-renewal is controlled by both extrinsic and intrinsic factors. The Bmp signal from niche cells controls GSC self-renewal by directly repressing a Bam-dependent differentiation pathway in GSCs. pelota...