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Keywords: Germline stem cell
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Journal Articles
Journal: Development
Development (2018) 145 (3): dev159178.
Published: 08 February 2018
... Drosophila ovarian germline stem cell niche formation, the status of Notch signaling in the cell can be reprogrammed. This is controlled via steroid-induced miR-125 , which targets a negative regulator of Notch signaling, Tom. Thus, miR-125 acts as a spatiotemporal coordinator between paracrine Notch and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4312–4323.
Published: 01 December 2016
... differentiation. In this study, we show that DNA damage retards germline stem cell (GSC) self-renewal and progeny differentiation in a Lok kinase-dependent manner in the Drosophila ovary. Both heatshock-inducible endonuclease I-CreI expression and X-ray irradiation can efficiently introduce double-strand breaks...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3449–3458.
Published: 01 October 2016
... cells causes Trithorax-dependent activation of Dpp and consequently germline stem cell tumors. Germline stem cell Drosophila ovary Escort cell Differentiation niche Decapentaplegic Polycomb repressive complex 1 (PRC1) Brahma Tissue-specific adult stem cells are important for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4647–4656.
Published: 01 December 2013
.... © 2013. Published by The Company of Biologists Ltd 2013 Drosophila Insulin Dilp Germline stem cell Intestinal stem cell Hematopoietic progenitor cell Neural stem cell Amino acid sensing Nutritional control Stem cells possess the ability to self-renew and also to...
Journal Articles
Journal: Development
Development (2013) 140 (3): 530–540.
Published: 01 February 2013
... to minimize susceptibility to differentiation factors. Drosophila female germline stem cells (GSCs) have short G1 and long G2 phases, and diet-dependent systemic factors often modulate G2. We previously observed that Cyclin E (CycE), a known G1/S regulator, is atypically expressed in GSCs during G2/M...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (23): 5087–5097.
Published: 01 December 2011
...Daniel Kirilly; Su Wang; Ting Xie Stem cell self-renewal is controlled by concerted actions of niche signals and intrinsic factors in a variety of systems. In the Drosophila ovary, germline stem cells (GSCs) in the niche continuously self-renew and generate differentiated germ cells that interact...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 4039–4050.
Published: 15 September 2011
.... Germline stem cell Soma Transposon Piwi Aubergine piRNAs Tudor Drosophila Propagation of all sexually reproducing organisms depends upon the faithful development and function of reproductive organs. In Drosophila , oogenesis requires the coordinated differentiation of two...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2461–2469.
Published: 01 August 2010
.... Here, we describe a novel role of TSC1/2 in controlling stem cell maintenance. We show that in the Drosophila ovary, disruption of either the Tsc1 or Tsc2 gene in germline stem cells (GSCs) leads to precocious GSC differentiation and loss. The GSC loss can be rescued by treatment with TORC1 inhibitor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3627–3635.
Published: 01 November 2009
...Zheng Guo; Zhaohui Wang The Drosophila ovary is an excellent system with which to study germline stem cell (GSC) biology. Two or three female GSCs are maintained in a structure called a niche at the anterior tip of the ovary. The somatic niche cells surrounding the GSCs include terminal filament...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2223–2234.
Published: 01 July 2009
...Saravanapriah Nadarajan; J. Amaranath Govindan; Marie McGovern; E. Jane Albert Hubbard; David Greenstein Fertility depends on germline stem cell proliferation, meiosis and gametogenesis, yet how these key transitions are coordinated is unclear. In C. elegans , we show that GLP-1/Notch signaling...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (12): 2579–2588.
Published: 15 June 2003
... Drosophila ovary, two or three germline stem cells (GSCs) have recently been shown to reside in a niche, in which terminal filaments (TFs) and cap cells are two major components. We report that signals from newly formed niches promote clonal expansion of GSCs during niche formation in the Drosophila ovary...