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Keywords: Germline
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Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (8): dev198150.
Published: 16 April 2021
...Peter K. Nicholls; David C. Page ABSTRACT In each generation, the germline is tasked with producing somatic lineages that form the body, and segregating a population of cells for gametogenesis. During animal development, when do cells of the germline irreversibly commit to producing gametes...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev198663.
Published: 09 March 2021
... Drosophila , however, have begun to reveal new roles of nuclear receptor signaling in peripheral tissues in controlling reproduction. Here, we identified Hormone receptor 4 (Hr4) as an oogenesis regulator required in the ovary and muscles. Global Hr4 knockdown leads to increased germline stem cell (GSC) loss...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev173781.
Published: 06 April 2020
.... Drosophila Germline Imaginal disc Intestine Regeneration In the early 1900s, Thomas Hunt Morgan turned his research focus to examine the genetic basis of heredity in the organism Drosophila , moving away from previous efforts that included studying the biology of regeneration in the flatworm...
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (1): dev183095.
Published: 03 January 2020
... current knowledge of how X chromosome inactivation, an important model for epigenetic gene regulation, is initiated and controlled during early human embryo development. X chromosome inactivation Human Germline Embryo XIST XACT Pluripotent stem cells The formation of heteromorphic (see...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev181180.
Published: 20 September 2019
.... , Mitchell , J. , Bagijn , M. P. , Cording , A. C. , Doebley , A.-L. , Goldstein , L. D. , Lehrbach , N. J. , Le Pen , J. , et al. ( 2012 ). piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans . Cell   150 , 88 - 99 . 10.1016/j.cell...
Journal Articles
Journal: Development
Development (2019) 146 (8): dev173195.
Published: 23 April 2019
... fertilized eggs. Aging germlines displayed both sporadic and population-wide changes. A small fraction of aging animals displayed endomitotic oocytes in the germline and other defects. By contrast, all animals displayed age-related decreases in germline size and function. As early as day 3 of adulthood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev161190.
Published: 28 August 2018
... differentiating progeny at the same time, remains a challenging question. The chromatin assembly factor CAF1 is a conserved histone chaperone, which assembles histones H3 and H4 onto newly synthesized DNA during replication and repair. Here, we have investigated the role of CAF1 in the maintenance of germline...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev163915.
Published: 06 June 2018
... germline cells. * Author for correspondence ( yutaka@ascidian.zool.kyoto-u.ac.jp ) Competing interests The authors declare no competing or financial interests. 28 1 2018 3 5 2018 © 2018. Published by The Company of Biologists Ltd 2018 http://www.biologists.com/user...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4643–4653.
Published: 15 December 2016
... PUF proteins FBF-1 and FBF-2 support germline progenitor maintenance by repressing production of meiotic proteins and use distinct mechanisms to repress their target mRNAs. We identify dynein light chain DLC-1 as an important regulator of FBF-2 function. DLC-1 directly binds to FBF-2 outside of the...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2016) 143 (17): 3154–3167.
Published: 01 September 2016
... isoforms compromises oogenesis, causing female sterility. We systematically explored roles of the two DOM isoforms during oogenesis using a cell type-specific knockdown approach. Despite their ubiquitous expression, DOM-A and DOM-B have non-redundant functions in germline and soma for egg formation. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2598–2609.
Published: 01 August 2015
...Christopher M. Smendziuk; Anat Messenberg; A. Wayne Vogl; Guy Tanentzapf Soma-germline interactions play conserved essential roles in regulating cell proliferation, differentiation, patterning and homeostasis in the gonad. In the Drosophila testis, secreted signalling molecules of the JAK-STAT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1745–1755.
Published: 15 May 2015
... somatic differentiation in germ cells. To investigate whether this is caused by the accumulation of somatic transcripts, we performed mRNA-seq on dissected germlines with and without P granules. Strikingly, we found that somatic transcripts do not increase in the young adult germline when P granules are...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2495–2501.
Published: 15 June 2013
...Harry G. Leitch; Austin Smith Naive pluripotency refers to the capacity of single cells in regulative embryos to engender all somatic and germline cell types. Only germ cells – conventionally considered to be unipotent – can naturally re-acquire pluripotency, by cycling through fertilisation...
Journal Articles
Journal: Development
Development (2013) 140 (5): 1014–1023.
Published: 01 March 2013
... Socs36E transcription and preventing hyperactivation of JAK-STAT signaling. dUTX also acts in germline stem cells to maintain hub structure through regulating DE-Cadherin levels. Therefore, our findings provide new insights into how an epigenetic factor regulates crosstalk among different cell types...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 487–491.
Published: 01 February 2013
.../EMBL symposium ‘Germline – Immortality through Totipotency’, researchers discussed the mechanisms that establish and control totipotency, with an eye towards the mechanisms that may endow germ cells with the ability to propagate totipotency across generations. * Authors for correspondence ( metp...
Journal Articles
Journal: Development
Development (2012) 139 (24): 4505–4513.
Published: 15 December 2012
...Jun Wei Pek; Bing Fu Ng; Toshie Kai In Drosophila , Maelstrom is a conserved component of the perinuclear nuage, a germline-unique structure that appears to serve as a site for Piwi-interacting RNA (piRNA) production to repress deleterious transposons. Maelstrom also functions in the nucleus as a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3301–3305.
Published: 15 September 2012
... differentiated cell types in the embryo and in vitro has been demonstrated. However, it has remained unclear whether haploid ESCs can contribute to the germline. Here, we show that parthenogenetic haploid ESCs at high passage have robust germline competence enabling the production of transgenic mouse strains...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1547–1556.
Published: 01 May 2012
...Yun Li; Jean Z. Maines; Ömür Y. Tastan; Dennis M. McKearin; Michael Buszczak In the Drosophila ovary, bone morphogenetic protein (BMP) ligands maintain germline stem cells (GSCs) in an undifferentiated state. The activation of the BMP pathway within GSCs results in the transcriptional repression of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (4): 783–792.
Published: 15 February 2012
... transporters Germline Multidrug Sea urchin Plasma membranes (PMs) function to control the flow of molecules between cells and their environment. ATP-binding cassette (ABC) transporters are PM proteins found in all cells that provide protection by exporting toxins ( Dean et al., 2001 ; Deeley...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3367–3376.
Published: 15 August 2011
...X. Rebecca Sheng; Erika Matunis Adult stem cells modulate their output by varying between symmetric and asymmetric divisions, but have rarely been observed in living intact tissues. Germline stem cells (GSCs) in the Drosophila testis are anchored to somatic hub cells and were thought to exclusively...
Includes: Multimedia, Supplementary data