...Alyshia Scholl; Yihong Liu; Geraldine Seydoux ABSTRACT In animals with germ plasm, embryonic germline precursors inherit germ granules, condensates proposed to regulate mRNAs coding for germ cell fate determinants. In Caenorhabditis elegans , mRNAs are recruited to germ granules by MEG-3...

...Celja J. Uebel; Sanjana Rajeev; Carolyn M. Phillips ABSTRACT RNA silencing pathways are complex, highly conserved, and perform crucial regulatory roles. In Caenorhabditis elegans germlines, RNA surveillance occurs through a series of perinuclear germ granule compartments – P granules, Z granules...

...Anne C. Campbell; Dustin L. Updike Germ granules (P granules) in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency. Sterility in the absence of P granules is often accompanied by the misexpression of soma-specific proteins and the initiation...

..., several connections between RNAi and germ granules have recently become apparent. Proteins involved in RNAi-related processes localize to germ granules (nuage or polar granules) in Drosophila ( Lim and Kai, 2007 ; Megosh et al., 2006 ; Pane et al., 2007 ) and to P bodies, RNP particles in somatic cells...

..., Pittsburgh, PA 15213, USA § Present address: Department of Basic Science, Bastyr University, Kenmore, WA 98028, USA 21 04 2000 13 06 2000 © 2000 by Company of Biologists 2000 Germ granules RNA helicases CCHC zinc fingers Glycine-rich repeats Combinatorial RNA-mediated...