... cells at the bipotential stage of gonad development. Double mutants lacking the functions of both Crabp2a and Crabp2b predominantly become male, which correlates with their smaller gonad size and reduced germ cell proliferation during gonad development at late larval and early juvenile stages...

... homology domain Cytoskeleton Cell polarity Gametogenesis Germ cell Spectraplakin Wellcome http://dx.doi.org/10.13039/100010269 080007 203144 092096 207496 Wellcome http://dx.doi.org/10.13039/100010269 Cancer Research UK http://dx.doi.org/10.13039/501100000289...

.... 60 , 580 - 587 . 10.1095/biolreprod60.3.580 Buccione , R. , Schroeder , A. C. and Eppig , J. J. ( 1990 ). Interactions between somatic cells and germ cells throughout mammalian oogenesis . Biol. Reprod. 43 , 543 - 547 . 10.1095/biolreprod43.4.543 Bullejos , M...

... zebrafish primordial germ cells that migrate throughout the developing embryo. When migrating within an ectodermal environment, the germ cells form fewer and smaller blebs when compared with their behavior within mesodermal environment. We find that cortical tension of neighboring cells is a parameter...

...Chun-Wei Feng; Guillaume Burnet; Cassy M. Spiller; Fiona Ka Man Cheung; Kallayanee Chawengsaksophak; Peter Koopman; Josephine Bowles ABSTRACT In mice, the entry of germ cells into meiosis crucially depends on the expression of stimulated by retinoic acid gene 8 ( Stra8 ). Stra8 is expressed...

... concentrations of S1P. These effects can be rescued by addition of the 12-Lox product 12-S-HETE. Blocking ABC transporter, PLA2 or 12-Lox activity also inhibits homing of germ cells in vivo . Using a live-imaging chemotaxis assay in a 3D matrix, we show that a shallow gradient of 12-S-HETE enhances chemotaxis...

.../user-licence-1-1/ Summary: Conditional deletion of the E2 SUMO-conjugating enzyme in mouse oocytes causes female infertility as a result of compound defects in ovarian follicle development and oocyte meiotic maturation and progression. Reproduction Fertility Germ cell Transcription...

... is involved in a variety of cellular processes, including ribosome biogenesis, cellular differentiation, germ cell development and tumorigenesis. However, the mechanisms by which prmt5 influences cellular processes have remained unclear. Here, prmt5 loss in zebrafish led to the expression of an infertile male...

...Kazuko Hanyu-Nakamura; Kazuki Matsuda; Stephen M. Cohen; Akira Nakamura ABSTRACT Specification of germ cells is pivotal to ensure continuation of animal species. In many animal embryos, germ cell specification depends on maternally supplied determinants in the germ plasm. Drosophila polar granule...

...Philip D. Campbell; Amanda E. Heim; Mordechai Z. Smith; Florence L. Marlow In animals, specification of the primordial germ cells (PGCs), the stem cells of the germ line, is required to transmit genetic information from one generation to the next. Bucky ball (Buc) is essential for germ plasm (GP...

... in culture. More recent work has shown that, in vivo , mammalian germ cells maintain poised chromatin at promoters of many genes that regulate somatic development, and that they retain this state from fetal stages through meiosis and gametogenesis. We hypothesize that the poised chromatin state is essential...

... In vertebrates that have been examined to date, the sexual identity of germ cells is determined by the sex of gonadal somatic cells. In the teleost fish medaka, a sex-determination gene on the Y chromosome, DMY / dmrt1bY , is expressed in gonadal somatic cells and regulates the sexual identity of germ cells...

...Lei Lei; Allan C. Spradling Mammalian germ cells divide mitotically and form nests of associated cells just prior to entering meiosis. At least some nests contain germline cysts that arise by synchronous, incomplete mitotic divisions, but others may form by aggregation. To systematically...

...Cassy M. Spiller; Chun-Wei Feng; Andrew Jackson; Ad J. M. Gillis; Antoine D. Rolland; Leendert H. J. Looijenga; Peter Koopman; Josephine Bowles Germ cells, the embryonic precursors of sperm or oocytes, respond to molecular cues that regulate their sex-specific development in the fetal gonads...

... a well-established role in regulating the survival and migration of germ cells. We now show that wun has an essential tissue-autonomous role in development of the trachea: the catalytic activity of Wun is required to maintain septate junction (SJ) paracellular barrier function, loss of which causes...

...Jason D. Heaney; Ericka L. Anderson; Megan V. Michelson; Jennifer L. Zechel; Patricia A. Conrad; David C. Page; Joseph H. Nadeau Testicular teratomas result from anomalies in germ cell development during embryogenesis. In the 129 family of inbred strains of mice, teratomas initiate around embryonic...

...-Str. 10, 8093 Zürich, Switzerland ¶ Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 10 5 2011 © 2011. 2011 Cxcr4 Cell migration Chemokine Evolution Germ cell Zebrafish...

...Maki Shirae-Kurabayashi; Kazuki Matsuda; Akira Nakamura In many animal embryos, germ-cell formation depends on maternal factors located in the germ plasm. To ensure the development of germ cells, germline progenitors must be prevented from differentiating inappropriately into somatic cells...

.... Strikingly, the first wave of spermatogenesis was totally compromised, as seminiferous tubules of homozygous mutant animals were devoid of post-meiotic germ cells. We determined that spermatogenesis was arrested around the late pachytene-diplotene stages of prophase I; surprisingly, without any obvious...

...Matthew S. Cook; Steven C. Munger; Joseph H. Nadeau; Blanche Capel Human germ cell tumors show a strong sensitivity to genetic background similar to Dnd1 Ter/Ter mutant mice, where testicular teratomas arise only on the 129/SvJ genetic background. The introduction of the Bax mutation onto mixed...