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Keywords: Genome engineering
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Journal Articles

An intersectional genetic approach for simultaneous cell type-specific labelling and gene knockout in the mouse

De-Fong Huang, Chao-Wen Lin, Tzu-Yin Yang, Cheng-Chang Lien, Chang-Hao Yang, Hsien-Sung Huang
Journal: Development
Development (2023) 150 (4): dev201198.
https://doi.org/10.1242/dev.201198
Published: 14 February 2023
... cellular subtypes and knock out specific genes in vivo . Cell labelling Cell type-specific Dre-rox Genome engineering Intersectional genetic approach Mouse Ministry of Science and Technology, Taiwan http://dx.doi.org/10.13039/501100004663 MOST 107-2628-B-002-004-MY3 MOST 109-2314...
View articletitled, An intersectional genetic approach for simultaneous cell type-specific labelling and gene knockout in the mouse
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Includes: Supplementary data
Journal Articles

Making designer mutants in model organisms

Ying Peng, Karl J. Clark, Jarryd M. Campbell, Magdalena R. Panetta, Yi Guo, Stephen C. Ekker
Journal: Development
Development (2014) 141 (21): 4042–4054.
https://doi.org/10.1242/dev.102186
Published: 1 November 2014
...Ying Peng; Karl J. Clark; Jarryd M. Campbell; Magdalena R. Panetta; Yi Guo; Stephen C. Ekker Recent advances in the targeted modification of complex eukaryotic genomes have unlocked a new era of genome engineering. From the pioneering work using zinc-finger nucleases (ZFNs), to the advent...
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Journal Articles

Efficient homologous recombination-mediated genome engineering in zebrafish using TALE nucleases

Jimann Shin, Jiakun Chen, Lilianna Solnica-Krezel
Journal: Development
Development (2014) 141 (19): 3807–3818.
https://doi.org/10.1242/dev.108019
Published: 1 October 2014
... in determining the efficiency of HR-mediated genome engineering. Implementing these modifications improved the efficiency of zebrafish knock-in generation, with over 10% of the injected F0 animals transmitting gene-targeting events through their germline. We generated two HR-mediated insertion alleles of sox2...
View articletitled, Efficient homologous recombination-mediated genome engineering in zebrafish using TALE nucleases
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Includes: Supplementary data