.... Little; Chad M. Vezina; Cathy Mendelsohn Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine...

...Congxing Lin; Yan Yin; G. Michael Veith; Alexander V. Fisher; Fanxin Long; Liang Ma Genital tubercle (GT) initiation and outgrowth involve coordinated morphogenesis of surface ectoderm, cloacal mesoderm and hindgut endoderm. GT development appears to mirror that of the limb. Although Shh...

... external genital development can be divided into two distinct phases: the first involves initial outgrowth and patterning of the genital tubercle, which occurs in both male and female embryos( George and Wilson, 1994 ); the second, hormonally controlled phase, involves either the continued growth...

... growth and differentiation of the genital tubercle (GT), an embryonic anlage of external genitalia, generates a proximodistally elongated structure suitable for copulation, erection, uresis and ejaculation. Despite recent progress in molecular embryology, few attempts have been made to elucidate...

... growth factor 10 ( Fgf10 ), in the anlage: the genital tubercle (GT). Activities of Shh for both GT outgrowth and differentiation were also demonstrated. Shh –/– mice displayed complete GT agenesis, which is compatible with such observations. Furthermore, the regulation of apoptosis during GT formation...

... that the developmental processes of its anlage, the genital tubercle (GT), have much in common with those of limb buds. The Fgf genes have been postulated as regulating several downstream genes during organogenesis. Fgf8 was expressed in the distal urethral plate epithelium of the genital tubercle (GT) together...

... , 2 – 5 ). In some transplants, hyaline cartilage and membrane bone of the p-segment fused immediately after differentiation, as seen in normal males, while in other transplants, neither component of the p-segment fused, at least during the course of the experiments. We used genital tubercles...