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Keywords: Genetics
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Journal Articles
Journal: Development
Development (2019) 146 (14): dev177261.
Published: 19 July 2019
... and the use of synthetic systems to test models. This highly dynamic, interdisciplinary mix of quantitative developmental genetics, bioengineering, synthetic biology and artificial life aimed to reveal how evolution exploits physical forces and genetics to implement the cell- and tissue-level decision-making...
Journal Articles
Journal: Development
Development (2018) 145 (20): dev164384.
Published: 22 October 2018
... leads to a complete failure to initiate the cardiac morphogenetic program ( Zhao et al., 2008 ) ( Fig. 4 E). In addition, genetic cooperativity between GATA4/5/6 has been demonstrated in compound heterozygote mice for Gata5 and either Gata4 or Gata6 , which exhibit pronounced heart defects...
Journal Articles
Journal: Development
Development (2018) 145 (1): dev151944.
Published: 03 January 2018
... leaflet maturation remains poorly understood. Here, we show in mouse that neural crest cells from pre-otic and post-otic regions make distinct contributions to the arterial valve leaflets. Genetic fate-mapping analysis of Krox20-expressing neural crest cells shows a large contribution to the borders...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1743–1763.
Published: 15 May 2017
... highlight additional Notch receptors or ligands that are likely to be involved in human genetic diseases. We thank Mattias Karlen for help with Figs 2 A, 3 A and 4 C,D, and the figures in Boxes 1 and 2 . Mutations across some Notch genes were mapped using HGMD ( Stenson et al., 2014 ). The authors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3994–4002.
Published: 01 November 2016
... showed reduced expression of multiple neuroretina-expressed FGFs and canonical FGF-regulated genes in neuroretina. When FGF expression was genetically restored in Lhx2 -deficient neuroretina of Chx10-Cre;Lhx2 lox/lox mice, we observed a partial but nonetheless substantial rescue of the defects in lens...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (5): 1105–1116.
Published: 01 March 2005
... for the cell rearrangements that spread the teleost blastoderm over the yolk. Epiboly Radial intercalation E-cadherin Epiblast Teleost Morphogenesis Genetics Antisense Zebrafish Here we report on the molecular identity and the cellular basis for the epiboly defects in mutant alleles...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (16): 3907–3920.
Published: 15 August 2004
... ribosomal protein mutation. * Author for correspondence (e-mail: tglaser@umich.edu ) 12 5 2004 ©2004. 2004 Mouse Genetics Minute Ribosome Cell cycle Retina Bst The Minutes are an intriguing group of eukaryotic mutations that have been valuable in elucidating...
Journal Articles
Journal: Development
Development (2003) 130 (17): 3917–3928.
Published: 01 September 2003
... understood. To identify genes required for the formation of vertebrate digestive organs we performed a genetic screen in zebrafish. We isolated the nil per os ( npo ) mutation,which arrests morphogenesis and cytodifferentiation of the gut and exocrine pancreas in a primodial state. We identified the npo gene...
Journal Articles
Journal: Development
Development (1993) 119 (Supplement): 9–18.
Published: 01 December 1993
... and also in response to lateral signalling that inhibits adjacent vulval precursor cells from both assuming the 1° fate. © The Company of Biologists Limited 1993 1993 development genetics C. elegans vulva EGF inter-cellular signalling ...
Journal Articles
Journal: Development
Development (1991) 113 (Supplement_2): 47–57.
Published: 01 April 1991
... the neurons and their axonal paths occur at close range and involve multiple, possibly combinatorial, transmitterindependent pathways. Copyright © 1991 by Company of Biologists 1991 genetics mutation zebrafish primary neuron notoneuron somite muscle notochord floor plate cell nteractions...