...Alexis Garretson; Beth L. Dumont; Mary Ann Handel ABSTRACT Genetic analyses of mammalian gametogenesis and fertility have the potential to inform about two important and interrelated clinical areas: infertility and contraception. Here, we address the genetics and genomics underlying gamete...

... and the use of synthetic systems to test models. This highly dynamic, interdisciplinary mix of quantitative developmental genetics, bioengineering, synthetic biology and artificial life aimed to reveal how evolution exploits physical forces and genetics to implement the cell- and tissue-level decision-making...

... mammalian development and emphasizes their pleiotropic role in cell lineage decisions and early organogenesis. GATA factors Gene redundancy Genetics Lineage specification Mouse development Transcription Human diseases Canadian Institutes of Health Research 10.13039/501100000024 MOP...

... leaflet maturation remains poorly understood. Here, we show in mouse that neural crest cells from pre-otic and post-otic regions make distinct contributions to the arterial valve leaflets. Genetic fate-mapping analysis of Krox20-expressing neural crest cells shows a large contribution to the borders...

... highlight additional Notch receptors or ligands that are likely to be involved in human genetic diseases. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. © 2017. Published by The Company of Biologists Ltd...

... showed reduced expression of multiple neuroretina-expressed FGFs and canonical FGF-regulated genes in neuroretina. When FGF expression was genetically restored in Lhx2 -deficient neuroretina of Chx10-Cre;Lhx2 lox/lox mice, we observed a partial but nonetheless substantial rescue of the defects in lens...

...: University of Virginia Health Systems, Department of Pathlogy, 415 Lane Road, Charlottesville, VA 22908, USA 29 12 2004 ©2005. 2005 Epiboly Radial intercalation E-cadherin Epiblast Teleost Morphogenesis Genetics Antisense Zebrafish Here we report on the molecular identity...

... ribosomal protein mutation. * Author for correspondence (e-mail: [email protected] ) 12 5 2004 ©2004. 2004 Mouse Genetics Minute Ribosome Cell cycle Retina Bst The Minutes are an intriguing group of eukaryotic mutations that have been valuable in elucidating...

... understood. To identify genes required for the formation of vertebrate digestive organs we performed a genetic screen in zebrafish. We isolated the nil per os ( npo ) mutation,which arrests morphogenesis and cytodifferentiation of the gut and exocrine pancreas in a primodial state. We identified the npo gene...

... 51, 79108 Freiburg, Germany 18 10 1995 © 1996 by Company of Biologists 1996 uniparental duplication imprinting translocation mouse genetics chromosome 7 Using interspecific hybrid backcross analysis, the Snrpn gene has been assigned as distal to the pink-eyed...

... of the antennal and eye structures (See Fig. 5 ). Genetic analysis of the developing fly has identified a growing class of genes that function in the development of multiple tissues. One such gene is Notch , which plays important roles in cell fate decisions in the embryonic neuroectoderm as well...

... Research, Mill Hill, London NW7, UK 28 11 1991 © 1992 by Company of Biologists 1992 coat colour genetics silver recessive spotting mouse melanocyte culture growth Melanocyte (pigment cell) lines are useful tools for molecular studies of germline coat-colour mutations...

... the neurons and their axonal paths occur at close range and involve multiple, possibly combinatorial, transmitterindependent pathways. Copyright © 1991 by Company of Biologists 1991 genetics mutation zebrafish primary neuron notoneuron somite muscle notochord floor plate cell nteractions...

...Dorothy C. Bennett; Dennis Huszar; Philip J. Laipis; Rudolf Jaenisch; Ian J. Jackson ABSTRACT A mouse cDNA for the developmentally controlled, melanocyte-specific protein, tyrosinase-related protein 1 (TRP-1), was previously cloned and reported to show genetic linkage with the coat-colour locus...

... of a cell and that there must be another developmental clock that activates the determinative inventory for the early decision-making. * Present address 17 10 1989 © 1990 by Company of Biologists 1990 C. elegans genetics stem cell determination developmental clock...

... the body wall. 24 03 1987 © 1987 by Company of Biologists 1987 Caenorhabditis elegans neurone migration genetics cell lineage axon Cells assemble into organs by selectively attaching to neighbouring cells. In animals, the final neighbours need not be close relatives...