...Alexis Garretson; Beth L. Dumont; Mary Ann Handel ABSTRACT Genetic analyses of mammalian gametogenesis and fertility have the potential to inform about two important and interrelated clinical areas: infertility and contraception. Here, we address the genetics and genomics underlying gamete...

... and the use of synthetic systems to test models. This highly dynamic, interdisciplinary mix of quantitative developmental genetics, bioengineering, synthetic biology and artificial life aimed to reveal how evolution exploits physical forces and genetics to implement the cell- and tissue-level decision-making...

... mammalian development and emphasizes their pleiotropic role in cell lineage decisions and early organogenesis. GATA factors Gene redundancy Genetics Lineage specification Mouse development Transcription Human diseases Canadian Institutes of Health Research 10.13039/501100000024 MOP...

... leaflet maturation remains poorly understood. Here, we show in mouse that neural crest cells from pre-otic and post-otic regions make distinct contributions to the arterial valve leaflets. Genetic fate-mapping analysis of Krox20-expressing neural crest cells shows a large contribution to the borders...

... highlight additional Notch receptors or ligands that are likely to be involved in human genetic diseases. * Author for correspondence ([email protected]) Competing interests The authors declare no competing or financial interests. © 2017. Published by The Company of Biologists Ltd 2017...

... showed reduced expression of multiple neuroretina-expressed FGFs and canonical FGF-regulated genes in neuroretina. When FGF expression was genetically restored in Lhx2 -deficient neuroretina of Chx10-Cre;Lhx2 lox/lox mice, we observed a partial but nonetheless substantial rescue of the defects in lens...

... of linkage group I. Genetics 139 , 1727 -1735. Kane, D. and Adams, R. (2002). Life at the edge: epiboly and involution in the zebrafish. In Gastrulation Movements. Vol. 40 (ed. L. Solnica-Krezel), pp. 117 -135. Heidelberg:Springer-Verlag. Kane, D. A. and Kimmel, C. B. (1993). The zebrafish...

... ribosomal protein mutation. * Author for correspondence (e-mail: [email protected]) 12 5 2004 ©2004. 2004 Mouse Genetics Minute Ribosome Cell cycle Retina Bst The Minutes are an intriguing group of eukaryotic mutations that have been valuable in elucidating...

... understood. To identify genes required for the formation of vertebrate digestive organs we performed a genetic screen in zebrafish. We isolated the nil per os (npo) mutation,which arrests morphogenesis and cytodifferentiation of the gut and exocrine pancreas in a primodial state. We identified the npo gene...

... on development . Development 113 , 679 – 688 . Beechey , C. V. and Cattanach , B. M. (1994). Genetic imprinting map . Mouse Genome 92 , 108 – 110 . Beechey , C. V. and Cattanach , B. M. (1995a). Genetic imprinting map . Mouse Genome 93 , 89 – 92 . Beechey...

... receptor retinoid X receptor oogenesis eye morphogenesis genetics 9-cis- retinoic acid The actions of the steroid, thyroid and retinoid hormones are predominantly mediated by the members of the steroid receptor superfamily. These receptors are ligand-dependent transcription factors that alter...

... kill melanocytes as they differentiate in each hair cycle (Jackson et al., 1990). Both si/si and rs/rs melanocytes grew more slowly than those of other genotypes, both in primary culture and after immortalization. Both mutations were on the genetic background of C57BL/6J, but the possibility...

... the neurons and their axonal paths occur at close range and involve multiple, possibly combinatorial, transmitterindependent pathways. Copyright © 1991 by Company of Biologists 1991 genetics mutation zebrafish primary neuron notoneuron somite muscle notochord floor plate cell nteractions...

...Dorothy C. Bennett; Dennis Huszar; Philip J. Laipis; Rudolf Jaenisch; Ian J. Jackson ABSTRACT A mouse cDNA for the developmentally controlled, melanocyte-specific protein, tyrosinase-related protein 1 (TRP-1), was previously cloned and reported to show genetic linkage with the coat-colour locus...

.... (1985). Plasticity of the differential state . Science 230 , 758 – 766 . 10.1126/science.2414846 Brenner , S. (1974). The genetics of C. elegans. Genetics 77 , 71 – 94 . Cowan , A. E. and McIntosh , J. R. (1985). Mapping the distribution of differentiation...

... the body wall. 24 03 1987 © 1987 by Company of Biologists 1987 Caenorhabditis elegans neurone migration genetics cell lineage axon Cells assemble into organs by selectively attaching to neighbouring cells. In animals, the final neighbours need not be close relatives...