... and the use of synthetic systems to test models. This highly dynamic, interdisciplinary mix of quantitative developmental genetics, bioengineering, synthetic biology and artificial life aimed to reveal how evolution exploits physical forces and genetics to implement the cell- and tissue-level decision-making...

... al., 2008 ) ( Fig. 4 E). In addition, genetic cooperativity between GATA4/5/6 has been demonstrated in compound heterozygote mice for Gata5 and either Gata4 or Gata6 , which exhibit pronounced heart defects and lethality ( Laforest and Nemer, 2011 ) ( Fig. 4 F). As expected for such crucial...

... leaflet maturation remains poorly understood. Here, we show in mouse that neural crest cells from pre-otic and post-otic regions make distinct contributions to the arterial valve leaflets. Genetic fate-mapping analysis of Krox20-expressing neural crest cells shows a large contribution to the borders...

... highlight additional Notch receptors or ligands that are likely to be involved in human genetic diseases. Jag1 and Notch2 also regulate inner ear development. Deafness and impaired balance have been identified in four ethylnitrosourea (ENU)-induced Jag1 mutant mouse strains: Slalom ( Tsai et al., 2001...

... showed reduced expression of multiple neuroretina-expressed FGFs and canonical FGF-regulated genes in neuroretina. When FGF expression was genetically restored in Lhx2 -deficient neuroretina of Chx10-Cre;Lhx2 lox/lox mice, we observed a partial but nonetheless substantial rescue of the defects in lens...

... for the cell rearrangements that spread the teleost blastoderm over the yolk. Epiboly Radial intercalation E-cadherin Epiblast Teleost Morphogenesis Genetics Antisense Zebrafish The expansion of the zebrafish epiblast seemed to show a remarkable blend of Xenopus and mouse morphogenesis...

... weeks and remained so into adulthood ( Fig. 1E,F ). * Author for correspondence (e-mail: tglaser@umich.edu ) 12 5 2004 ©2004. 2004 Mouse Genetics Minute Ribosome Cell cycle Retina Bst The Minutes are an intriguing group of eukaryotic mutations that have...

... understood. To identify genes required for the formation of vertebrate digestive organs we performed a genetic screen in zebrafish. We isolated the nil per os ( npo ) mutation,which arrests morphogenesis and cytodifferentiation of the gut and exocrine pancreas in a primodial state. We identified the npo gene...

... and also in response to lateral signalling that inhibits adjacent vulval precursor cells from both assuming the 1° fate. © The Company of Biologists Limited 1993 1993 development genetics C. elegans vulva EGF inter-cellular signalling ...

... the neurons and their axonal paths occur at close range and involve multiple, possibly combinatorial, transmitterindependent pathways. Development Supplement 2, 1991, 47-57 Printed in Great Britain © The Company of Biologists Limited 1991 47 Genetic control of primary neuronal development in zebrafish CHARLES...