.... Summary: The auxin-inducible degradation (AID) system is adapted to C. elegans to enable conditional depletion of degron-tagged protein targets in as little as twenty minutes. C. elegans Genetic tool Degron Auxin Auxin-inducible degradation Tissue-specific depletion Techniques...

... and is often incompletely effective ( Asikainen et al., 2005 ; Fire et al., 1998 ; Kamath et al., 2001 ). Here, we introduce ZF1 tagging as a novel approach to rapidly and acutely inactivate gene function at the protein level with spatial and temporal resolution. ZF1 tagging provides a powerful genetic tool...