... that modulate the severity of the phenotype. Although several genetic modifier loci have been mapped in mice, the gene(s) residing at these loci are mostly unidentified, and the molecular mechanisms of modifier action remain poorly understood. Mutations in Sox18 cause a variable phenotype in the human...

... and characterization of candidate genes that may contribute to human agnathia-holoprosencephaly complex diseases. *Author for correspondence (e-mail: [email protected] ) 11 6 2002 © 2002. 2002 Otx2 Otocephaly Agnathia-holoprosencephaly complex Genetic modifier Neural crest Mandible...