... Neuromesodermal progenitors Nkx1-2 Body axis elongation Genetic lineage tracing Mouse embryo The Nkx1-2 coding sequence in exon 1 and the splice donor site at the junction between exon 1 and intron 1 were replaced with the open reading frame of tamoxifen-inducible CreER T2 recombinase as depicted...

... genetic lineage tracing method, and genetic data, we show that the competence to embark on a neuronal or sensory fate is provided sequentially and very early during otic placode induction. Loss of Foxi1 prevents neuronal precursor formation without affecting hair cell specification, whereas loss of Dlx3b...