... activation and repression; it remains to be tested which function of E2F is critical for normal development. Drosophila homologs of the RB and E2F family of proteins RBF and dE2F1 have been identified. The genetic interactions between rbf and de2f1 were analyzed during Drosophila development, and the results...

... , L. , Rijli , F. M. , Chambon , P. and Krumlauf , R. ( 1998 ). Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning . Development , 125 , 1025 – 1036 . Swiatek , P. J. and Gridley , T. ( 1993 ). Perinatal...

... inhibition signal. 15 07 1997 © 1997 by Company of Biologists 1997 big brain Notch Delta neurogenesis lateral inhibition Drosophila genetic interaction The first step in the development of the Drosophila nervous system is the specification of neural precursors (NPs...

... mutant mice are more extensive, including strong reductions in length, complete absences, or improper segmentations of many metacarpal and phalangeal bones. Additionally, the d4 carpal bone is not properly formed and often produces an extra rudimentary digit. To examine the genetic interactions between...

... based genetic method, enhancer piracy, to drive ectopic expression of a rho cDNA transgene by endogenous genomic enhancers. Many enhancer piracy transposon- rho insertions cause dominant phenotypes, over half of which cannot be duplicated by ubiquitous expression of rho . Genetic interactions between...