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Keywords: Gene repression
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Journal Articles

Sox2- Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain

Ivelisse Cajigas, Abhijit Chakraborty, Madison Lynam, Kelsey R. Swyter, Monique Bastidas, Linden Collens, Hao Luo, Ferhat Ay, Jhumku D. Kohtz
Journal: Development
Development (2021) 148 (6): dev197202.
https://doi.org/10.1242/dev.197202
Published: 15 March 2021
... on chromosome 6 in mouse developing forebrain. Here, we show that Evf2 long-range gene repression occurs through multi-step mechanisms involving the transcription factor Sox2. Evf2 directly interacts with Sox2, antagonizing Sox2 activation of Dlx5/6UCE , and recruits Sox2 to the Dlx5/6eii shadow enhancer...
View article titled, Sox2- Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain
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Includes: Supplementary data
Journal Articles

C. elegans synMuv B proteins regulate spatial and temporal chromatin compaction during development

Meghan E. Costello, Lisa N. Petrella
Journal: Development
Development (2019) 146 (19): dev174383.
https://doi.org/10.1242/dev.174383
Published: 1 October 2019
... or financial interests. 29 11 2018 4 9 2019 © 2019. Published by The Company of Biologists Ltd 2019 Summary: C. elegans synMuv B proteins regulate chromatin compaction preceding upregulation of zygotic gene expression to ensure proper gene repression and cell fate decisions...
View article titled, C. elegans synMuv B proteins regulate spatial and temporal chromatin compaction during development
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Includes: Supplementary data