... to investigate neural crest development. Neural crest Mouse Zebrafish Xenopus Chicken Gene knockout Introduction The neural crest is a multipotent stem cell population unique to vertebrates that contributes to development of the peripheral nervous system, craniofacial skeleton, adrenal...

... © 2008. 2008 Adrenal cortex β-Catenin Cre-loxP Gene knockout Steroidogenic factor 1 The adrenal cortex is part of the hypothalamic-pituitary-adrenal (HPA) axis that mediates the response to stress through synthesis and release of corticosteroid hormones. Although...

... for mouse fetal development. Nature 374 , 640 -643. * Author for correspondence (e-mail: [email protected] ) 3 4 2007 © 2007. 2007 Autonomic nervous system bHLH transcription factor Conditional knockout Enteric nervous system Gene knockout Gut development Mouse...

... Inner ear development Semicircular ducts Gene knockout Mouse Cell proliferation The vertebrate inner ear is derived from one of three pairs of sensory placodes located in the anterior embryonic ectoderm. The other two placodes located more rostrally will contribute to the development...

... ) 8 3 2001 © 2001. 2001 Nuclear receptor Retinoic acid Gene knockout Transcriptional activity Activation function Placenta Limb Mouse Retinoids (vitamin A derivatives) are crucial for many aspects of vertebrate physiology and homeostasis (reviewed in Sporn et al., 1994...

...-bs.de ) 22 02 1999 19 04 1999 © 1999 by Company of Biologists 1999 Homeodomain transcription factor Gene knockout Gut Spleen Development Growth regulation Nkx2-3 Mouse Gut development in vertebrates begins with the invagination of the endodermal layer, first...

... ) 22 01 1998 21 11 1997 © 1998 by Company of Biologists 1998 Homeobox gene Inner ear Pregnancy Gene knockout Mouse The Hmx homeobox gene family was first identified in humans ( Stadler et al., 1992 ) and subsequently in a number of species ranging from Drosophila...

... 1996 © 1997 by Company of Biologists 1997 retinoic acid receptors morphogenesis gene knockout mouse embryonic development genetic redundancy Vitamin A is important for many aspects of vertebrate physiology ( Wolbach and Howe, 1925 ; see Sporn et al., 1994 and Blomhoff...