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Keywords: Gene expression
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Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (9): dev200568.
Published: 6 May 2022
... expression remains unclear. Depletion of molecular factors (e.g. CTCF) underlying topologically associating domains (TADs) leads to modest alterations in gene expression, whereas genomic rearrangements involving TAD boundaries disrupt normal gene expression and can lead to pathological phenotypes. Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200491.
Published: 28 March 2022
... in Drosophila promotes growth in both males and females, but the underlying genetic, transcriptional and metabolic mechanisms are not fully shared between the sexes. Sex difference Diet Insulin Gene expression Metabolism Body size Drosophila Canadian Institutes of Health Research http...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2021) 148 (13): dev199589.
Published: 6 July 2021
... cells rapidly diversify from each other, and investigation of the corresponding gene expression dynamics can help elucidate underlying cellular differentiation programs. However, current plant embryonic transcriptome datasets either lack cell-specific information or have RNA contamination from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199018.
Published: 12 June 2021
... and concomitantly undergo stronger downregulation by knockdown of either the intracellular Ca 2+ release channel IP 3 R or Set2. IP 3 /Ca 2+ signals thus regulate gene expression through Set2-mediated H3K36 marks on select neuronal genes for the larval to pupal transition. Competing interests The authors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev194019.
Published: 23 December 2020
...Ian J. Begeman; Kwangdeok Shin; Daniel Osorio-Méndez; Andrew Kurth; Nutishia Lee; Trevor J. Chamberlain; Francisco J. Pelegri; Junsu Kang ABSTRACT Heart regeneration in regeneration-competent organisms can be accomplished through the remodeling of gene expression in response to cardiac injury...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev186452.
Published: 14 August 2020
... by The Company of Biologists Ltd 2020 Summary: This Spotlight gives an overview of the discovery and current understanding of transcriptional adaptation, and discusses how its main features appear to be conserved across species. Transcriptional adaptation Gene expression Genetic compensation...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (11): 1976–1987.
Published: 1 June 2017
... deposited in Gene Expression Omnibus with entry GSE97579. Sections (7 µm thick) were obtained from placental samples embedded in paraffin and processed as described previously ( Chi and Delgado-Olguin, 2013 ). GFP + endothelial cells were sorted from control ( G9a fl/+ ;Tie2-Cre;Rosa mT/mG...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 345–355.
Published: 15 January 2017
...Anna Reade; Laura B. Motta-Mena; Kevin H. Gardner; Didier Y. Stainier; Orion D. Weiner; Stephanie Woo ABSTRACT Here, we describe an optogenetic gene expression system optimized for use in zebrafish. This system overcomes the limitations of current inducible expression systems by enabling robust...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2882–2897.
Published: 15 August 2016
...Swetansu K. Hota; Benoit G. Bruneau Precise gene expression ensures proper stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian development. ATP-dependent chromatin-remodeling complexes utilize the energy from ATP hydrolysis to reorganize chromatin...
Journal Articles
Journal: Development
Development (2016) 143 (7): 1217–1227.
Published: 1 April 2016
... of genes along the apical-basal and dorsal-ventral axes in the globular embryo, which tended to fluctuate in later developmental stages. We also analyzed gene expression patterns in the early globular embryo and how this relates to expression in embryonic organs at later stages. We confirmed the accuracy...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (3): 540–546.
Published: 1 February 2016
...L. Carine Stapel; Benoit Lombardot; Coleman Broaddus; Dagmar Kainmueller; Florian Jug; Eugene W. Myers; Nadine L. Vastenhouw Analysis of differential gene expression is crucial for the study of cell fate and behavior during embryonic development. However, automated methods for the sensitive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3073–3076.
Published: 15 September 2015
... and Newcastle, UK, was established to provide embryonic and fetal material for a variety of human studies ranging from single gene expression analysis to large-scale genomic/transcriptomic studies. Increasingly, HDBR material is enabling the derivation of stem cell lines and contributing towards developments...
Journal Articles
Journal: Development
Development (2015) 142 (8): 1418–1430.
Published: 15 April 2015
... gene expression during mesoderm induction. We find that Brg1 co-localizes with H3K27ac at distal enhancers and is required for robust H3K27 acetylation at distal enhancers that are activated during mesoderm induction. Brg1 is also required to maintain Polycomb-mediated repression of non-mesodermal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4158–4167.
Published: 1 November 2014
...Ahmet Ay; Jack Holland; Adriana Sperlea; Gnanapackiam Sheela Devakanmalai; Stephan Knierer; Sebastian Sangervasi; Angel Stevenson; Ertuğrul M. Özbudak The vertebrate segmentation clock is a gene expression oscillator controlling rhythmic segmentation of the vertebral column during embryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2939–2949.
Published: 1 August 2014
... permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Pancreas development Endocrine progenitor cells Gene expression Transcription factors Mouse The genetic program responsible for the generation of pancreatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (12): 2524–2532.
Published: 15 June 2014
... the atlas-builder software to benefit a large proportion of the developmental biology community, and the eNeuro atlas to serve as a publicly accessible hub for integrating neuronal attributes – cell lineage, gene expression patterns, axon/dendrite projections, neurotransmitters – and linking them...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3385–3394.
Published: 15 August 2013
.... * Authors for correspondence ( jmurr@mail.med.upenn.edu ; arjunraj@seas.upenn.edu ) Competing interests statement The authors declare no competing financial interests. 10 6 2013 © 2013. Published by The Company of Biologists Ltd 2013 Cell division Gene expression RNA FISH...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2818–2822.
Published: 1 July 2013
...Benedetta Artegiani; Federico Calegari Generation of transgenic mice, in utero electroporation and viral injection are common approaches to manipulate gene expression during embryonic development of the mammalian brain. While very powerful in many contexts, these approaches are each characterized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (22): 4172–4179.
Published: 15 November 2012
... statement The authors declare no competing financial interests. 6 8 2012 © 2012. 2012 Cohesin Polycomb Gene expression Control of gene expression is vital to normal development. During Drosophila development, spatially and temporally restricted DNA-binding transcriptional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 3891–3896.
Published: 1 November 2012
... laboratory (Cornell University, Ithaca, USA) updated the meeting on recent studies showing the importance of the transcriptional repressor TRIM28 for imprinted gene expression, work that was undertaken in collaboration with Mathieu Boulard and Timothy Bestor (Columbia University, New York, USA). Maternal...