...Katsiaryna Maskalenka; Gökberk Alagöz; Felix Krueger; Joshua Wright; Maria Rostovskaya; Asif Nakhuda; Adam Bendall; Christel Krueger; Simon Walker; Aylwyn Scally; Peter J. Rugg-Gunn ABSTRACT Gene duplication events can drive evolution by providing genetic material for new gene functions...

...Susanna Streubel; Michael André Fritz; Melanie Teltow; Christian Kappel; Adrien Sicard ABSTRACT Gene duplication is a major driver for the increase of biological complexity. The divergence of newly duplicated paralogs may allow novel functions to evolve, while maintaining the ancestral one...

... its insertion in the hoxb5b locus increased reporter expression and rendered it more similar to that of hoxb5a . Our results highlight the importance of interactions between CNEs in the execution of complementary subfunctions of duplicated genes. Duplication events, which can affect anything...

...-specific gene duplication. We show that both paralogues acquired novel functions, both at the level of their cis-regulation as well as through significant divergence of the coding sequence. Both genes are expressed in the hypostome, but HyBra1 is predominantly endodermal, whereas HyBra2 transcripts...

... in the craniofacial skeleton of homozygous sox9b b971 animals result from loss of sox9b function. * These authors contributed equally to this work 22 12 2004 ©2005. 2005 Chondrogenesis Craniofacial Gene duplication Genome duplication Limb morphogenesis Skeletogenesis...

... of these two genes. After gene duplication, one of the paralogous genes is often lost from the genome due to its redundant function( Prince and Pickett, 2002 ). If duplicated genes acquire non-redundant functions, then both are likely to be retained ( Force et al., 1999 ). In the case of the pcdh15 zebrafish...

... at the end of the manuscript 20 10 2004 © 2004. 2004 Zebrafish Hematopoiesis Transferrin receptor Iron Gene duplication Iron acquisition by developing erythroid cells is necessary to produce hemoglobin, which allows red blood cells to deliver oxygen to body tissues...

...-mail: [email protected] ) 9 4 2001 © 2001. 2001 Hox Vertebrate Zebrafish Gene duplication Hindbrain Midbrain Mauthner neurone MLF Clustered Hox genes encode a conserved family of transcription factors implicated in providing regional identity along the anteroposterior...

... of Biologists 1998 Slug, Snail Mouse Chick Zinc-finger transcription factor Neural crest Mesoderm Gene duplication Chordate Vertebrate Evolution Much of the progress made in our understanding of developmental processes over recent years has been the result of the identification...

... that are again unique to vertebrates. We are interested in the genetic changes that may have permitted the origin of these inno vations. Gene duplication, followed by functional diver gence of new genes, may be one class of mutation that permits major evolutionary change. Here we examine the hypothesis that gene...