... 2023 Epigenetics Gene dosage Mary Lyon X-chromosome inactivation Xist Since 1961, when Mary Lyon first proposed the hypothesis of random X-chromosome inactivation (XCI), now known as Lyonization in her honour, numerous studies have confirmed her hypothesis. XCI consists...

...://www.biologists.com/user-licence-1-1/ Summary: Analysis of a hypomorphic Six3 allele reveals that variability in Six3 dosage is sufficient to generate mice exhibiting a spectrum of holoprosencephaly forms in a non-strain-specific manner. Six3 Holoprosencephaly Transcription factor Gene dosage...

... ) Competing interests statement 1 12 2010 © 2011. Dkk1 Lrp6 β-Catenin ENU mutant WNT signalling Head formation Mouse Gene dosage Formation of the head of the mouse embryo is accomplished by the coordinated regulation of specification, differentiation...

.... Multipotential retinal progenitors Ciliary epithelium SOX2 PAX6 Gene dosage Mouse The vertebrate eye, which is composed of neurogenic and non-neurogenic structures, arises from a single progenitor pool in the optic vesicle. The eye, therefore, provides a useful and accessible model...

... in Gdf11 rescue, to a considerable degree, the major defects in Foxg1 -/- OE,including the early, severe loss of neural precursors and olfactory receptor neurons, and the subsequent collapse of both neurogenesis and nasal cavity formation. Rescue is gene-dosage dependent, with loss of even one allele...

... neurons during early and late differentiation of midbrain dopaminergic neurons. Interestingly, genetic evidence indicates that these functions require different gene dosages of Foxa1 and Foxa2 . Altogether, our results demonstrate that Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic...

.... * Author for correspondence (e-mail: [email protected] ) 4 4 2007 © 2007. 2007 Adrenal development Gene dosage Organogenesis Mouse The adrenal cortex and gonad are the main steroid-producing tissues in mammals. Although they produce different steroid hormones...

... oligodendrocytes arguing that this process is as sensitive to Sox10 gene dosage as the development of melanocytes and the enteric nervous system ( Britsch et al., 2001 ; Herbarth et al.,1998a ; Pingault et al.,1998 ; Southard-Smith et al.,1998 ). The delay of terminal oligodendrocyte differentiation...

... from the rest of the plant,these mutants could make the meristem less sensitive to the signal needed for meristem conversion (this is equivalent to raising the signaling threshold). Fig. 9. Gene dosage model for SM and SPM identity. SPMs are wild type (green) with even one dose of ids1...

... for correspondence (e-mail: [email protected] ) 23 10 2001 © 2002. 2002 Pitx2 Pitx1 Gata2 Allelic series Gene dosage Cell specification Mouse The mammalian Pitx gene family consists of three bicoid-related homeobox genes, each with an important role in the development...

...-type embryos fail to elicit malformations in RXR α homozygotes, implicating RXRα as a component in the teratogenic process in the limbs. Heterozygous embryos are intermediate in sensitivity to RA, suggesting the importance of RXRα gene dosage in limb teratogenesis. Expression of the RA-inducible gene...