...://www.biologists.com/user-licence-1-1/ Summary: Analysis of a hypomorphic Six3 allele reveals that variability in Six3 dosage is sufficient to generate mice exhibiting a spectrum of holoprosencephaly forms in a non-strain-specific manner. Six3 Holoprosencephaly Transcription factor Gene dosage...

... ) Competing interests statement 1 12 2010 © 2011. Dkk1 Lrp6 β-Catenin ENU mutant WNT signalling Head formation Mouse Gene dosage Formation of the head of the mouse embryo is accomplished by the coordinated regulation of specification, differentiation...

.... Multipotential retinal progenitors Ciliary epithelium SOX2 PAX6 Gene dosage Mouse The vertebrate eye, which is composed of neurogenic and non-neurogenic structures, arises from a single progenitor pool in the optic vesicle. The eye, therefore, provides a useful and accessible model...

... in Gdf11 rescue, to a considerable degree, the major defects in Foxg1 -/- OE,including the early, severe loss of neural precursors and olfactory receptor neurons, and the subsequent collapse of both neurogenesis and nasal cavity formation. Rescue is gene-dosage dependent, with loss of even one allele...

... neurons during early and late differentiation of midbrain dopaminergic neurons. Interestingly, genetic evidence indicates that these functions require different gene dosages of Foxa1 and Foxa2 . Altogether, our results demonstrate that Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic...

.... * Author for correspondence (e-mail: amanda.swain@icr.ac.uk ) 4 4 2007 © 2007. 2007 Adrenal development Gene dosage Organogenesis Mouse The adrenal cortex and gonad are the main steroid-producing tissues in mammals. Although they produce different steroid hormones...

...., 2002 ). Sox proteins can be divided into 10 groups numbered A-J, with groups B-F being represented by at least one member in Drosophila and in all vertebrate model organisms( Bowles et al., 2000 ; Wegner, 1999 ). Sry High-mobility-group Sox10 Redundancy Gene dosage Oligodendrocyte...

... rgo Maize inflorescence development Nonallelic noncomplementation Spikelet Meristem identity Gene dosage ids1 Plant growth consists of reiterative developmental events that determine the morphology of the mature organism. Meristems, self organizing pools of undifferentiated cells...

... for correspondence (e-mail: scamper@umich.edu ) 23 10 2001 © 2002. 2002 Pitx2 Pitx1 Gata2 Allelic series Gene dosage Cell specification Mouse The mammalian Pitx gene family consists of three bicoid-related homeobox genes, each with an important role in the development...