... that Lrig1 acts through this mechanism to inhibit Ret activity. However, it is unclear whether other Lrig family members play similar roles. Here, we show that Lrig1 and Lrig3 are co-expressed in Ret-positive mouse dorsal root ganglion (DRG) neurons. Lrig3, like Lrig1, interacts with Ret and inhibits GDNF...

... occurrence has led to speculation of a ‘Janus mutation’ in RET that causes overactivation or impairment of RET activity depending on the cellular context. Using an intestinal catenary culture system to test the effects of GDNF-mediated RET activation, we demonstrate the concurrent development of distal...

... of the prostatic epithelium. However, the nature of the AR-regulated morphogenetic genes and the mechanisms whereby AR controls prostate development are not understood. Glial cell line-derived neurotrophic factor (GDNF) binds GDNF family receptor α1 (GFRα1) and signals through activation of RET tyrosine kinase...

... neurotrophic factor (GDNF) and its receptor GFRα1 are expressed in the forebrain, the role of this system in the hippocampus remains unclear. Here, we investigated the consequences of GFRα1 deficiency for the development of hippocampal connections. Analysis of conditional Gfra1 knockout mice shows a reduction...

... are poorly defined. In this study we identify glial cell line-derived neurotrophic factor (GDNF) as a key player in this process. GDNF displays a dynamic expression pattern during embryonic development that parallels the chronology of migration and differentiation of neural crest derivatives in the pancreas...

... for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 18 2 2011 © 2011. 2011 Zebrafish GDNF Head muscle Musculoskeletal Movement, eating and vocalisation require the action of functionally related...

.... To investigate Sulf regulation of developmental signaling, we have disrupted Sulf genes in mouse and identified redundant functions of Sulfs in GDNF-dependent neural innervation and enteric glial formation in the esophagus, resulting in esophageal contractile malfunction in Sulf1 -/- ;Sulf2 -/- mice. SULF1...

..., we found that Gdnf expression was dramatically reduced in both nephronectin- andα8 integrin-null mutants specifically in the metanephric mesenchyme at the time of ureteric bud invasion. We show that this reduction is sufficient to explain the agenesis and hypoplasia observed in both mutants...

... remains obscure. We demonstrate here that conditional ablation of GFR α 1 ,the high affinity receptor for GDNF, in mice during late gestation induces rapid and widespread neuronal death in the colon, leading to colon aganglionosis reminiscent of Hirschsprung's disease. Enteric neuron death induced by GFR...

...Naoya Asai; Toshifumi Fukuda; Zaiqi Wu; Atsushi Enomoto; Vassilis Pachnis; Masahide Takahashi; Frank Costantini The RET receptor tyrosine kinase plays a critical role in the development of the enteric nervous system (ENS) and the kidney. Upon glial-cell-line-derived neurotrophic factor (GDNF...

...Sanjay Jain; Cathy K. Naughton; Mao Yang; Amy Strickland; Kiran Vij; Mario Encinas; Judy Golden; Akshay Gupta; Robert Heuckeroth; Eugene M. Johnson, Jr; Jeffrey Milbrandt The Ret receptor tyrosine kinase mediates physiological signals of glial cell line-derived neurotrophic factor (GDNF) family...

.... The experimentally induced dysmorphology associated with deregulated expression of Wnt11 , Gdnf and Fgf7 genes in the early stages of organogenesis indicated a crucial role for sprouty function in coordination of epithelial-mesenchymal and stromal signalling, the sites of expression of these genes. Moreover, Fgf7...

...Iain T. Shepherd; Jacy Pietsch; Stone Elworthy; Robert N. Kelsh; David W. Raible Components of the zebrafish GDNF receptor complex are expressed very early in the development of enteric nervous system precursors, and are already present as these cells begin to enter the gut and migrate caudally...

...Pontus C. Holm; Francisco J. Rodríguez; Adelheid Kresse; Josep M. Canals; Inmaculada Silos-Santiago; Ernest Arenas The role of glial cell-line derived neurotrophic factor (GDNF) and neurotrophins in the development of locus coeruleus noradrenergic neurons was evaluated. We found that two...

... branching morphogenesis defects and consequent kidney hypoplasia in newborn mice. Wnt11 functions, in part, by maintaining normal expression levels of the gene encoding glial cell-derived neurotrophic factor (Gdnf). Gdnf encodes a mesenchymally produced ligand for the Ret tyrosine kinase receptor...

...-mail: [email protected] ) 4 4 2003 © 2003. 2003 Six1 Kidney development Eya1 Pax2 Six2 Sall1 Metanephric mesenchyme Apoptosis Gdnf Mouse The development of permanent kidney starts at around embryonic day (E) 11 in the mouse from the metanephric mesenchyme...

.... These analyses demonstrate that glial cell line-derived neurotrophic factor (GDNF) and neurturin are important for different aspects of ENS development. Neurturin is essential for maintaining the size of mature enteric neurons and the extent of neuronal projections, but does not influence enteric neuron number...

... tyrosine kinase RET and glial cell-derived neurotrophic factor (GDNF) form a signaling complex that is essential for ureteric bud growth and branching morphogenesis of the ureteric bud epithelium. We demonstrate that Pax2 expression in the metanephric mesenchyme is independent of induction by the ureteric...

... ganglion pioneer axons to grow toward their targets have yet to be determined. Here, we show that glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN) constitute target-derived factors for developing ciliary ganglion neurons. Both GDNF and NRTN are secreted from eye muscle located...

... in mice lacking GDNF. Nature 382 , 76 -79. Nigam, S. K. ( 1995 ). Determinants of branching tubulogenesis. Curr. Opin. Nephrol. Hypertens . 4 , 209 -214. Ohuchi, H., Hori, Y., Yamasaki, M., Harada, H., Sekine, K., Kato, S. and Itoh, N. ( 2000 ). FGF10 acts as a major ligand for FGF...