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Keywords: Gcm1
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Journal Articles

Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function

In collection:
Reproductive biology
Lauretta A. Lacko, Romulo Hurtado, Samantha Hinds, Michael G. Poulos, Jason M. Butler, Heidi Stuhlmann
Journal: Development
Development (2017) 144 (13): 2469–2479.
DOI: https://doi.org/10.1242/dev.147025
Published: 1 July 2017
... in branching morphogenesis, Gcm1 , Syna and Synb , and in patterning of the extracellular matrix, Mmrn1 , were temporally dysregulated in the placentas. Egfl7 knockout did not affect expression of the microRNA embedded within intron 7. Collectively, these data reveal that Egfl7 is crucial for placental...
View article titled, Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function
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Includes: Supplementary data
Journal Articles

p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth

Muhammed Kashif, Andrea Hellwig, Alexandre Kolleker, Khurrum Shahzad, Hongjie Wang, Siegfried Lang, Juliane Wolter, Madhusudhan Thati, Ilya Vinnikov, Angelika Bierhaus, Peter P. Nawroth, Berend Isermann
Journal: Development
Development (2011) 138 (11): 2235–2247.
DOI: https://doi.org/10.1242/dev.059105
Published: 1 June 2011
... and embryonic growth. Expression of p45NF-E2 in labyrinthine trophoblast cells colocalizes with that of Gcm1, a transcription factor crucial for syncytiotrophoblast formation. In the absence of p45NF-E2, the width of syncytiotrophoblast layer 2 and the expression of Gcm1 and Gcm1-dependent genes ( Synb...
View article titled, p45NF-E2 represses <span class="search-highlight">Gcm1</span> in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth
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Includes: Supplementary data
Journal Articles

Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth

David G. Simmons, David R. C. Natale, Valerie Begay, Martha Hughes, Achim Leutz, James C. Cross
Journal: Development
Development (2008) 135 (12): 2083–2091.
DOI: https://doi.org/10.1242/dev.020099
Published: 15 June 2008
... of these cell types have not previously been elucidated. We report here the discovery of cell-layer-restricted genes in the mid-gestation labyrinth (E12.5-14.5)including Ctsq in S-TGCs (also Hand1- positive), Syna in syncytiotrophoblast layer I (SynT-I), and Gcm1,Cebpa and Synb in syncytiotrophoblast layer II...
View article titled, Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth
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